ReviewFrontiers in cell and developmental biology2022
Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems.
Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Major Depressive Disorder Signatures: A Review of Artificial Intelligence (AI)-Powered Insights Into Gut Dysbiosis.Health science reports · 2026Article
- Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms.Environment international · 2026Article
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
- Spiritual walking and stress resilience integrating psychological endocrine and genetic evidence from a longitudinal Iraqi cohort.Discover mental health · 2026Article
- Association Between Systemic Inflammation Response Index and Specific Depressive Symptoms: Evidence From a Cross-Sectional Survey.Brain and behavior · 2026Article
- Verbascoside reverses GABAergic deficits in the prefrontal cortex to alleviate chronic Stress-Induced depression.Psychopharmacology · 2026Article
- Addictive drug abuse and depression-a focus on epigenetics.Communications biology · 2026Review
- EpiBrain: the brain's epigenetic landscape in a snapshot.bioRxiv : the preprint server for biology · 2026Article
- Harnessing Nanocarriers to Improve Psychiatric Treatment: Progress, Limitations, and Future Directions.International journal of nanomedicine · 2026Review
- Molecular Mechanisms of Depression: The Interplay Between Genes and Receptors.International journal of molecular sciences · 2025Review
- Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases.International journal of molecular sciences · 2025Review
- Early Life Stress and Major Depressive Disorder-An Update on Molecular Mechanisms and Synaptic Impairments.Molecular neurobiology · 2024Review
- Review
- Psychogenic Aging: A Novel Prospect to Integrate Psychobiological Hallmarks of Aging.Translational psychiatry · 2024Review
- Adverse effects of early-life stress: focus on the rodent neuroendocrine system.Neural regeneration research · 2024Review
- Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism.International journal of general medicine · 2024Review
- Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder.Translational psychiatry · 2023Review
- Remembering through the genome: the role of chromatin states in brain functions and diseases.Translational psychiatry · 2023Review
- Connexin 43 regulates astrocyte dysfunction and cognitive deficits in early life stress-treated mice.Experimental brain research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression has an alarmingly high prevalence worldwide. A growing body of evidence indicates that environmental factors significantly affect the neural development and function of the central nervous system and then induce psychiatric disorders. Early life stress (ELS) affects brain development and has been identified as a major cause of depression. It could promote susceptibility to stress in adulthood. Recent studies have found that ELS induces epigenetic changes that subsequently affect transcriptional rates of differentially expressed genes. The epigenetic modifications involved in ELS include histone modifications, DNA methylation, and non-coding RNA. Understanding of these genetic modifications may identify mechanisms that may lead to new interventions for the treatment of depression. Many reports indicate that different types of ELS induce epigenetic modifications of genes involved in the neurotransmitter systems, such as the dopaminergic system, the serotonergic system, the gamma-aminobutyric acid (GABA)-ergic system, and the glutamatergic system, which further regulate gene expression and ultimately induce depression-like behaviors. In this article, we review the effects of epigenetic modifications on the neurotransmitter systems in depression-like outcomes produced by different types of ELS in recent years, aiming to provide new therapeutic targets for patients who suffer from depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.