Evidence map›Paper›PMID 35865548›Full record

ReviewFrontiers in immunology2022

Radiotheranostic Agents in Hematological Malignancies.

Jo Caers, Elodie Duray, Louise Vrancken, Guillaume Marcion, Valentina Bocuzzi, Kim De Veirman, Ahmet Krasniqi, Margaux Lejeune, Nadia Withofs, Nick Devoogdt and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Current landscape and clinical progress of targeted alpha radioimmunotherapy.American journal of nuclear medicine and molecular imaging · 2025
    Review
  6. CD38 as theranostic target in oncology.Journal of translational medicine · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Integrating Theranostics Into Patient Care Pathways:AJR. American journal of roentgenology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jo CaersLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Elodie DurayLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Louise VranckenLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Guillaume MarcionLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Valentina BocuzziLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Kim De VeirmanDepartment of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Ahmet KrasniqiLaboratory of In Vivo Cellular and Molecular Imaging Laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium.
Margaux LejeuneLaboratory of Hematology, GIGA I³, University of Liège, Liège, Belgium.
Nadia WithofsDepartment of Nuclear Medicine, CHU de Liège, Liège, Belgium.
Nick DevoogdtLaboratory of In Vivo Cellular and Molecular Imaging Laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium.
Mireille DumoulinCentre for Protein Engineering, Inbios, University of Liège, Liège, Belgium.
Amelie Eriksson KarlströmDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Matthias D'HuyvetterLaboratory of In Vivo Cellular and Molecular Imaging Laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium.
University of Liège · BEVrije Universiteit Brussel · BECentre Hospitalier Universitaire de Liège · BEKTH Royal Institute of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of CD20 positive non-Hodgkin lymphoma decades ago, it never found a broad clinical application. In recent years, researchers have developed theranostic agents based on Ab fragments or small Ab mimetics such as peptides, affibodies or single-chain Abs with improved tumor-targeting capacities. Theranostics combine diagnostic and therapeutic capabilities into a single pharmaceutical agent; this dual application can be easily achieved after conjugation to radionuclides. The past decade has seen a trend to increased specificity, fastened pharmacokinetics, and personalized medicine. In this review, we discuss the different strategies introduced for the noninvasive detection and treatment of hematological malignancies by radiopharmaceuticals. We also discuss the future applications of these radiotheranostic agents.

Indexed as

Hematologic NeoplasmsLymphoma, Non-HodgkinNeoplasmsAntibodies, MonoclonalAntibodies, NeoplasmHumansRadioimmunotherapyAntibodies, MonoclonalAntibodies, Neoplasmleukemialymphomamultiple myelomaradionuclideradiotheranostic

Identifiers

PMID35865548
PMCPMC9294596
OpenAlexW4283805729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.