ReviewCureus2022
Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Shared genetic architecture between depression and migraine: a large-scale genome-wide cross-trait analysis.The journal of headache and pain · 2026Article
- Association of migraine with subsequent risk of depression or anxiety by small-area deprivation: national cohort study with sibling analysis.The journal of headache and pain · 2026Article
- Prevalence and associated factors of anxiety and depression among women seeking digital mental health services in Bangladesh.PLOS mental health · 2026Article
- Tracking migraine outcomes over time by age and monoclonal antibody type: a retrospective, single-center, real-world study.Frontiers in neurology · 2026Observational
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- The Role of Inflammation in Migraine Headaches: A Review.FASEB bioAdvances · 2025Review
- Article
- MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review.Genes · 2025Review
- A Hybrid Digital-4E Strategy for comorbid migraine and depression: a medical hypothesis on an AI-driven, neuroadaptive, and exposome-aware approach.Frontiers in neurology · 2025Article
- A Narrative Review of Intestinal Microbiota's Impact on Migraine with Psychopathologies.International journal of molecular sciences · 2024Review
- Early maladaptive schemas in female patients with migraine and tension-type headache.Scientific reports · 2024Article
- Identification of genetic susceptibility for Chinese migraine with depression using machine learning.Frontiers in neurology · 2024Article
- Effects of Fremanezumab on Psychiatric Comorbidities in Difficult-to-Treat Patients with Chronic Migraine: Post Hoc Analysis of a Prospective, Multicenter, Real-World Greek Registry.Journal of clinical medicine · 2023Article
- Anxiety and depression and health-related quality of life among adults with migraine: a National Population-Based Study.Frontiers in public health · 2023Article
- The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study.Frontiers in neurology · 2023Article
- Efficacy, tolerability and barriers to the use of anti-CGRP medications among migraine patients in Egypt: real world experience.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature to explore the association between migraine and depression. Genetic overlap of various gene segments was studied, and heritability patterns were explored. Shared mechanisms such as serotonergic dysfunction, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and hormonal effects were investigated, and commonalities like comorbidities, stress, and environmental factors were analyzed. Migraine with comorbid depression (MID) affects various aspects of life and its clinical impact on migraine disability, quality of life (QOL), progression, and medication overuse was investigated. We further inspected several types of research in order to provide options on various treatment modalities. Pharmacotherapy such as antidepressants and anti-Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies like fremanezumab were studied. Alternative treatment options such as onabotulinumtoxinA (OBTA) injections, cognitive behavioral therapy (CBT), and vagal nerve stimulations (VNS) were also appraised and the efficacies of each were compared.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.