Evidence map›Paper›PMID 35865076›Full record

ArticlePlant direct2022

The long road of functional recruitment-The evolution of a gene duplicate to pyrrolizidine alkaloid biosynthesis in the morning glories (Convolvulaceae).

Arunraj Saranya Prakashrao, Till Beuerle, Ana Rita G Simões, Christina Hopf, Serhat Sezai Çiçek, Thomas Stegemann, Dietrich Ober, Elisabeth Kaltenegger

Open access · goldAbstract read
In one paragraph

Article in Plant direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. The Antioxidant and Anti-Inflammatory Properties ofAntioxidants (Basel, Switzerland) · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Arunraj Saranya PrakashraoDepartment Biochemical Ecology and Molecular Evolution, Botanical Institute Christian-Albrechts-University Kiel Germany.
Till BeuerleInstitute of Pharmaceutical Biology Technische Universität Braunschweig Braunschweig Germany.
Ana Rita G SimõesRoyal Botanic Gardens, Kew Richmond UK.ORCID https://orcid.org/0000-0001-7267-8353
Christina HopfDepartment of Structural Biology, Zoological Institute Christian-Albrechts-University Kiel Germany.ORCID https://orcid.org/0000-0002-6709-6081
Serhat Sezai ÇiçekDepartment of Pharmaceutical Biology, Pharmaceutical Institute Christian-Albrechts-University Kiel Germany.ORCID https://orcid.org/0000-0002-3038-8523
Thomas StegemannDepartment Biochemical Ecology and Molecular Evolution, Botanical Institute Christian-Albrechts-University Kiel Germany.ORCID https://orcid.org/0000-0002-0391-3337
Dietrich OberDepartment Biochemical Ecology and Molecular Evolution, Botanical Institute Christian-Albrechts-University Kiel Germany.
Elisabeth KalteneggerDepartment Biochemical Ecology and Molecular Evolution, Botanical Institute Christian-Albrechts-University Kiel Germany.ORCID https://orcid.org/0000-0001-6542-1509
Christian-Albrechts-Universität zu Kiel · DERoyal Botanic Gardens, Kew · GBTechnische Universität Braunschweig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In plants, homospermidine synthase (HSS) is a pathway-specific enzyme initiating the biosynthesis of pyrrolizidine alkaloids (PAs), which function as a chemical defense against herbivores. In PA-producing Convolvulaceae ("morning glories"), HSS originated from deoxyhypusine synthase at least >50 to 75 million years ago via a gene duplication event and subsequent functional diversification. To study the recruitment of this ancient gene duplicate to PA biosynthesis, the presence of putative

Indexed as

deoxyhypusine synthaseDistimakegene duplicationhomospermidine synthaseIpomoeamolecular evolutionpyrrolizidine alkaloids

Identifiers

PMID35865076
PMCPMC9295680
OpenAlexW4286262943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.