Evidence map›Paper›PMID 35864853›Full record

ArticleJournal of cancer prevention2022

Formoxanthone C Inhibits Malignant Tumor Phenotypes of Human A549 Multidrug Resistant-cancer Cells through Signal Transducer and Activator of Transcription 1-Histone Deacetylase 4 Signaling.

Chutima Kaewpiboon, Nawong Boonnak, Sirichat Kaowinn, Natpaphan Yawut, Young-Hwa Chung

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer prevention, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Chutima Kaewpiboon *Department of Biology, Faculty of Science, Thaksin University, Phatthalung, Thailand.ORCID https://orcid.org/0000-0003-2519-3796
Nawong BoonnakDepartment of Basic Science and Mathematics, Faculty of Science, Thaksin University, Songkhla, Thailand.ORCID https://orcid.org/0000-0002-6230-5438
Sirichat KaowinnDepartment of General Science and Liberal Arts, King Mongkut's Institute of Technology Ladkrabang Prince of Chumphon Campus, Chumphon, Thailand.ORCID https://orcid.org/0000-0002-5945-917X
Natpaphan YawutDepartment of Cogno-Mechatronics Engineering, Pusan National University, Busan, Korea.ORCID https://orcid.org/0000-0002-7201-6576
Young-Hwa Chung *Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Korea.ORCID https://orcid.org/0000-0001-5738-7400
Pusan National University · KRThaksin University · THKing Mongkut's Institute of Technology Ladkrabang · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering that presence of cancer stem cell (CSC) subpopulation in tumor tissues confers anticancer drug resistance, we investigated whether human A549 lung cancer cells resistant to etoposide possess CSC-like phenotypes. Furthermore, it is known that these malignant tumor features are the leading cause of treatment failure in cancer. We have thus attempted to explore new therapeutic agents from natural products targeting these malignancies. We found that formoxanthone C (XanX), a 1,3,5,6-tetraoxygenated xanthone from

Indexed as

Cancer stem cell-like phenotypesFormoxanthone CHistone deacetylase 4Multidrug resistant-cancerSignal transducer and activator of transcription 1

Identifiers

PMID35864853
PMCPMC9271403
OpenAlexW4283806283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.