Evidence map›Paper›PMID 35864775›Full record

ArticleJournal of biomechanical engineering2023

Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure.

Yuanjia Zhu, Robert J Wilkerson, Pearly K Pandya, Danielle M Mullis, Catherine A Wu, Sarah Madira, Mateo Marin-Cuartas, Matthew H Park, Annabel M Imbrie-Moore, Y Joseph Woo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Biomechanical engineering analysis of neochordae length's impact on chordal forces in mitral repair.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304; Department of Bioengineering, Stanford University, Stanford, CA 94304.
Robert J WilkersonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304.
Pearly K PandyaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304; Department of Mechanical Engineering, Stanford University, Stanford, CA 94304.
Danielle M MullisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304.
Catherine A WuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304.
Sarah MadiraDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304.
Mateo Marin-CuartasDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304; University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig 04289, Germany.
Matthew H ParkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304; Department of Mechanical Engineering, Stanford University, Stanford, CA 94304.
Annabel M Imbrie-MooreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94304; Department of Mechanical Engineering, Stanford University, Stanford, CA 94304.
Y Joseph WooFalk Cardiovascular Research Center Department of Cardiothoracic Surgery, Stanford University, MD 300 Pasteur Drive, Stanford, CA 94305; Department of Bioengineering, Stanford University, Stanford, CA 94304.
Stanford University · USLeipzig Heart Institute · DE

Funding

Biomechanical Optimization of Mitral Valve Repair OperationsR01HL152155 · NHLBI · STANFORD UNIVERSITY · PI WOO, Y JOSEPH · 2020 to 2025
$5.9M
Biomechanical Optimization of Mitral Valve Repair Operations and Annuloplasty Rings for Primary Mitral Valve RegurgitationF32HL158151 · NHLBI · STANFORD UNIVERSITY · PI ZHU, YUANJIA · 2021 to 2022
$144k
National Science Foundation DGE-1656518NHLBI NIH HHS F32 HL158151NHLBI NIH HHS R01 HL152155
6 · The paper itself

Abstract

The Ross procedure using the inclusion technique with anticommissural plication (ACP) is associated with excellent valve hemodynamics and favorable leaflet kinematics. The objective was to evaluate individual pulmonary cusp's biomechanics and fluttering by including coronary flow in the Ross procedure using an ex vivo three-dimensional-printed heart simulator. Ten porcine and five human pulmonary autografts were harvested from a meat abattoir and heart transplant patients. Five porcine autografts without reinforcement served as controls. The other autografts were prepared using the inclusion technique with and without ACP (ACP and NACP). Hemodynamic and high-speed videography data were measured using the ex vivo heart simulator. Although porcine autografts showed similar leaflet rapid opening and closing mean velocities, human ACP compared to NACP autografts demonstrated lower leaflet rapid opening mean velocity in the right (p = 0.02) and left coronary cusps (p = 0.003). The porcine and human autograft leaflet rapid opening and closing mean velocities were similar in all three cusps. Porcine autografts showed similar leaflet flutter frequencies in the left (p = 0.3) and noncoronary cusps (p = 0.4), but porcine NACP autografts versus controls demonstrated higher leaflet flutter frequency in the right coronary cusp (p = 0.05). The human NACP versus ACP autografts showed higher flutter frequency in the noncoronary cusp (p = 0.02). The leaflet flutter amplitudes were similar in all three cusps in both porcine and human autografts. The ACP compared to NACP autografts in the Ross procedure was associated with more favorable leaflet kinematics. These results may translate to the improved long-term durability of the pulmonary autografts.

Indexed as

Heart Valve ProsthesisPulmonary ValveAnimalsAortic ValveAutograftsBiomechanical PhenomenaHemodynamicsHumansSwineTransplantation, Autologous

Identifiers

PMID35864775
PMCPMC9445321
OpenAlexW4286697469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.