SynthesisAmerican journal of men's health
The Efficacy and Safety of HoLEP for Benign Prostatic Hyperplasia With Large Volume: A Systematic Review and Meta-Analysis.
Synthesis in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Ejaculation-preserving holmium laser enucleation of the prostate: a systematic review of techniques, functional outcomes, and safety.World journal of urology · 2026Pooled it
- 1470 nm diode laser enucleation versus bipolar transurethral resection of the prostate for the surgical management of benign prostatic hyperplasia: a randomized comparison.Lasers in medical science · 2025Trial
- Comparative analysis of low-power versus high-power holmium laser enucleation of the prostate for symptomatic small-volume benign prostatic hyperplasia: a prospective randomized controlled trial.The Journal of international medical research · 2024Trial
- Transperineal Laser Ablation of Symptomatic Benign Prostatic Hyperplasia With Median-Lobe Enlargement: A Single-Center Experience.Lasers in surgery and medicine · 2026Article
- HoLEP for large and mega glands: real-world outcomes and evidence of size-enhanced efficiency.International urology and nephrology · 2026Article
- Review
- Pulsed Thulium:YAG laser enucleation versus open simple prostatectomy for large-gland benign prostatic hyperplasia: a retrospective comparative observational study.Translational andrology and urology · 2026Article
- Article
- Real-World outcomes of aquablation for benign prostatic hyperplasia: a comparative analysis of the international collaborative aquablation research urology society (ICARUS) database, WATER and WATER-II trials.World journal of urology · 2026Article
- A retrospective study comparing holmium Laser enucleation vs. transurethral resection for the treatment of benign prostatic hyperplasia.Frontiers in surgery · 2026Article
- One-night catheter stay after Holmium laser enucleation of the prostate: a single-center comparative study.International urology and nephrology · 2026Article
- Functional outcomes and safety profile of thulium: YAG laser enucleation (ThuLEP) versus robot-assisted simple prostatectomy (RASP) facing very large (≥ 150 ml) prostates.World journal of urology · 2025Article
- Article
- Review
- Review
- Application effect of pelvic floor function exercise based on health belief model in patients with benign prostatic hyperplasia after electrocautery.International urology and nephrology · 2025Article
- Refractory metabolic acidosis and acute abdominal compartment syndrome following Holmium Laser Enucleation of Prostate (HoLEP).Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- MoLEP vs. HoLEP for BPH: A 3-Year Greek Single-Center Retrospective Comparative Cohort Study on 1368 Cases.Cancers · 2025Article
- Robotic prostatectomy for large-volume prostates in prostate cancer: a retrospective analysis of 50 cases (>100 ml).BMC cancer · 2025Article
- Influence of preoperative indwelling urinary catheter on outcomes of high-power holmium laser enucleation for very large prostate (≥ 200 mL).World journal of urology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was to evaluate the efficacy and safety of holmium laser enucleation of prostate (HoLEP) in the treatment of benign prostatic hyperplasia (BPH) with large volume. PubMed, Embase, and Cochrane Library databases (until March 2022) were used to search related randomized controlled trials. A total of 11 studies including 1,258 patients were involved. HoLEP could significantly decrease the length of hospital stay and accelerate recovery. In subanalysis, HoLEP had better perioperative outcomes than bipolar transurethral resection of the prostate (B-TURP) and bipolar transurethral enucleation of the prostate (BPEP). The improvement in operative time and enucleation time was better in thulium laser enucleation of the prostate (ThuLEP) than HoLEP. In the follow-up period, the HoLEP decreased post-void residual urine (PVR) in short-term intervals and improved patients' maximum flow rate (Qmax) and prostate-specific antigen (PSA) in mid- and long-term intervals. In subanalysis, HoLEP presented significant improvements in Qmax, PSA, and quality of life (QoL) than B-TURP, and HoLEP could also improve Qmax than ThuLEP after 6 months of surgery. The HoLEP reduced the risk of postoperative bleeding compared with other surgeries in safety. In our study, we confirmed the advantages of HoLEP in treating BPH when the prostate size was larger than 80 mL, which indicated that HoLEP could be the best choice for treatment of large volume of prostate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.