ArticleJournal of orthopaedic surgery and research2022
Neutrophil-lymphocyte ratio as a potential marker for differential diagnosis between spinal tuberculosis and pyogenic spinal infection.
Article in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 19 citations in OpenAlex.
- Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part I-Epidemiology, Clinical Features, Laboratory Markers, and Tissue-Based Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- A drop of blood, a hint of risk: neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as early predictors and risk stratifiers in pyogenic spondylodiscitis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The Prognostic Value of the Neutrophil-to-lymphocyte Ratio in Older Patients with Pulmonary Tuberculosis.Internal medicine (Tokyo, Japan) · 2026Article
- Utility of CBC-derived ratios in the diagnosis and prediction of active tuberculosis in people with rheumatic diseases.BMC infectious diseases · 2026Article
- Wasting phenotype for differentiating spinal tuberculosis from spinal pyogenic infection.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Preoperative differentiation of spinal tuberculosis, pyogenic, and brucellar spondylitis: a multimodal machine learning study across five centers.Frontiers in cellular and infection microbiology · 2026Article
- Machine learning-based feature selection suggests circulating proteins as best at predicting and diagnosing tuberculosis inFrontiers in cellular and infection microbiology · 2026Article
- A four-year misdiagnosis of spinalIDCases · 2026Article
- An Unusual Presentation of Spinal Tuberculosis Masquerading as Pyogenic Meningitis: A Case Report.Case reports in medicine · 2026Article
- Incremental value of quantitative SPECT/CT integrated parameters in a multimodal machine-learning model for differentiating spinal tuberculosis from pyogenic spondylitis.Frontiers in cellular and infection microbiology · 2026Article
- Neutrophil-lymphocyte ratio: a correlation study of its effect on magnetic resonance imaging enhancement patterns in spinal parenchymal tuberculosis.BMC infectious diseases · 2025Article
- Diagnostic Significance of Hematological Parameters and Ratios in the Context ofInfection and drug resistance · 2025Article
- Unlocking the Diagnostic Potential: A Systematic Review of Biomarkers in Spinal Tuberculosis.Journal of clinical medicine · 2024Review
- Development and validation of a diagnostic model to differentiate spinal tuberculosis from pyogenic spondylitis by combining multiple machine learning algorithms.Biomolecules & biomedicine · 2024Article
- Neutrophil-to-lymphocyte ratio and its association with latent tuberculosis infection and all-cause mortality in the US adult population: a cohort study from NHANES 2011-2012.Frontiers in nutrition · 2024Article
- Diagnostic value of the neutrophil lymphocyte ratio in discrimination between tuberculosis and bacterial community acquired pneumonia: AJournal of clinical tuberculosis and other mycobacterial diseases · 2023Review
- Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Monocyte Ratio, Platelet-to-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Psoriasis Patients: Response to Treatment with Biological Drugs.Journal of clinical medicine · 2023Article
- A predictive model for early clinical diagnosis of spinal tuberculosis based on conventional laboratory indices: A multicenter real-world study.Frontiers in cellular and infection microbiology · 2023Article
- A Predictive Clinical-Radiomics Nomogram for Differentiating Tuberculous Spondylitis from Pyogenic Spondylitis Using CT and Clinical Risk Factors.Infection and drug resistance · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDistinguishing spinal tuberculosis and pyogenic spinal infection is extremely important. The neutrophil-lymphocyte ratio (NLR), a simple indicator, has been shown to be a novel inflammatory marker. The objective of our study was to determine whether the NLR could be a potential indicator for discriminating spinal tuberculosis (STB) from pyogenic spinal infection (PSI).
methodsWe compared the clinical and laboratory characteristics of 146 patients diagnosed with STB and 60 participants with PSI from the First Affiliated Hospital of Nanjing Medical University. The NLR's diagnostic ability for differential diagnosis was assessed and compared to other hematological indicators, including the platelet-lymphocyte ratio (PLR).
resultsThe NLR in STB patients was considerably lower than that in PSI patients [3.85 (2.70-5.71) vs. 10.82 (6.79-17.62), P < 0.001]. An NLR of 6.742 was proposed as an optimal cutoff value for distinguishing patients with STB from those with PSI (sensitivity 78.33%, specificity 83.56%). However, the NLR's area under the curve [0.87, 95% confidence interval (CI) 0.81-0.92] was considerably higher than that of the PLR (0.73, 95% CI 0.65-0.80; P < 0.0001).
conclusionNLR levels could be a valuable laboratory diagnostic for distinguishing patients with STB from those who have PSI.
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