Evidence map›Paper›PMID 35864503›Full record

ReviewCancer cell international2022

Functional interplay between long non-coding RNAs and Breast CSCs.

Bashdar Mahmud Hussen, Ramiar Kamal Kheder, Sara Tharwat Abdullah, Hazha Jamal Hidayat, Heshu Sulaiman Rahman, Abbas Salihi, Mohammad Taheri, Soudeh Ghafouri-Fard

Open access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Circular RNAs: key regulators in cancer stem cell dynamics.Molecular genetics and genomics : MGG · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. A review on the role of HAND2-AS1 in cancer.Clinical and experimental medicine · 2023
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Bashdar Mahmud HussenDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil , Kurdistan Region, Iraq.
Ramiar Kamal KhederDepartment of Medical Analysis, Faculty of Science, Tishk International University, Erbil, Iraq.
Sara Tharwat AbdullahDepartment of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Hazha Jamal HidayatDepartment of Biology, College of Education, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Heshu Sulaiman RahmanDepartment of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, Republic of Iraq.
Abbas SalihiDepartment of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Mohammad TaheriUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad.taheri@uni-jena.de.
Soudeh Ghafouri-FardDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.
Salahaddin University-Erbil · IQHawler Medical University · IQJena University Hospital · DEKomar University of Science and Technology · IQLebanese French University · IQShahid Beheshti University of Medical Sciences · IRUniversity of Raparin · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) represents aggressive cancer affecting most women's lives globally. Metastasis and recurrence are the two most common factors in a breast cancer patient's poor prognosis. Cancer stem cells (CSCs) are tumor cells that are able to self-renew and differentiate, which is a significant factor in metastasis and recurrence of cancer. Long non-coding RNAs (lncRNAs) describe a group of RNAs that are longer than 200 nucleotides and do not have the ability to code for proteins. Some of these lncRNAs can be mainly produced in various tissues and tumor forms. In the development and spread of malignancies, lncRNAs have a significant role in influencing multiple signaling pathways positively or negatively, making them promise useful diagnostic and prognostic markers in treating the disease and guiding clinical therapy. However, it is not well known how the interaction of lncRNAs with CSCs will affect cancer development and progression.Here, in this review, we attempt to summarize recent findings that focus on lncRNAs affect cancer stem cell self-renewal and differentiation in breast cancer development and progression, as well as the strategies and challenges for overcoming lncRNA's therapeutic resistance.

Indexed as

Breast cancer (BC)Breast CSC (BrCSC)Cancer stem cells (CSCs)lncRNAsTherapeutic resistance

Identifiers

PMID35864503
PMCPMC9306174
OpenAlexW4286494085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.