ArticleNature communications2022
Post-translational amino acid conversion in photosystem II as a possible origin of photosynthetic oxygen evolution.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
- Three rate-determining protein roles in photosynthetic ONature communications · 2025Article
- Mutation-induced shift of the photosystem II active site reveals insight into conserved water channels.The Journal of biological chemistry · 2024Article
- Interplay of two low-barrier hydrogen bonds in long-distance proton-coupled electron transfer for water oxidation.PNAS nexus · 2023Article
- Mutation of a metal ligand stabilizes the high-spin form of the SPhotosynthesis research · 2023Article
- Electron-Transfer Route in the Early Oxidation States of the MnThe journal of physical chemistry. B · 2023Article
- Cyanophages as an important factor in the early evolution of oxygenic photosynthesis.Scientific reports · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
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Abstract
Photosynthetic oxygen evolution is performed at the Mn cluster in photosystem II (PSII). The advent of this reaction on ancient Earth changed its environment by generating an oxygenic atmosphere. However, how oxygen evolution originated during the PSII evolution remains unknown. Here, we characterize the site-directed mutants at the carboxylate ligands to the Mn cluster in cyanobacterial PSII. A His residue replaced for D1-D170 is found to be post-translationally converted to the original Asp to recover oxygen evolution. Gln/Asn residues in the mutants at D1-E189/D1-D342 are also converted to Glu/Asp, suggesting that amino-acid conversion is a common phenomenon at the ligand sites of the Mn cluster. We hypothesize that post-translational generation of carboxylate ligands in ancestral PSII could have led to the formation of a primitive form of the Mn cluster capable of partial water oxidation, which could have played a crucial role in the evolutionary process of photosynthetic oxygen evolution.
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