Observational studyBMJ open2022
Gastric cancer incidence, mortality and burden in adolescents and young adults: a time-trend analysis and comparison among China, South Korea, Japan and the USA.
Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Machine Learning-Based Survival Prediction Models for Young Patients With Gastric Cancer: Model Development and Validation Study.JMIR cancer · 2026Article
- Risk Stratification in Primary Gastric Malignancies in Children, Adolescents, and Young Adults: A SEER-Based Analysis.Journal of personalized medicine · 2026Article
- Use of free blood in the stomach to diagnose gastric mucosal lesions prior to endoscopy: the Sanguis-filum.BMC research notes · 2026Article
- One cancer, two stories: divergent estimates of gastric cancer burden in Korea.Archives of public health = Archives belges de sante publique · 2026Article
- CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.Discover oncology · 2025Article
- Comparative study of early onset cancer burden between China and the United States from 1990 to 2021.Scientific reports · 2025Article
- Trends and Disparities in Mortality Due to Gastric Malignancies the United States: A Nationwide Analysis from 1999 to 2020.Journal of gastrointestinal cancer · 2025Article
- Disulfidptosis-related LncRNA signatures in gastric cancer: regulation of MYH10-driven cytoskeletal remodeling and therapeutic implications.Discover oncology · 2025Article
- Long-term outcomes of laparoscopic distal gastrectomy for locally advanced gastric cancer: An individual patient data meta-analysis of KLASS-02 and CLASS-01 randomized controlled trials.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Adolescents and young adults with germline CDH1 variants and the risk of overtreatment.Journal of the National Cancer Institute · 2025Article
- Gut microbiota, circulating metabolites, and pancreatic cancer risk: a multi-method causal inference study with cross-population validation.Frontiers in microbiology · 2025Article
- Long-term relative survival of patients with gastric cancer from a large-scale cohort: a period-analysis.BMC cancer · 2024Article
- Trends in mortality from gastrointestinal, hepatic, and pancreatic cancers in the United States: A comprehensive analysis (1999-2020).JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Gastric cancer with Fanconi anemia in adolescent and young adult patient diagnosed by comprehensive genome profiling using next-generation sequencing.Clinical journal of gastroenterology · 2024Article
- The Role of Methionine Restriction in Gastric Cancer: A Summary of Mechanisms and a Discussion on Tumor Heterogeneity.Biomolecules · 2024Review
- Lentinan progress in inflammatory diseases and tumor diseases.European journal of medical research · 2024Review
- GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy.Biology direct · 2024Article
- Metastasis patterns and prognosis in young gastric cancer patients: A propensity score‑matched SEER database analysis.PloS one · 2024Article
- The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells.Contemporary oncology (Poznan, Poland) · 2024Article
- Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes.Journal of gastrointestinal oncology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate and compare the burden of gastric cancer in adolescents and young adults (GCAYA) among China, South Korea, Japan and the USA, four countries with similar or different rates of gastric cancer (GC) incidence, development levels and cancer control strategies.
designThis population-based observational study collected the epidemiological data of GCAYA from the Global Burden of Diseases Study 2019. The trend magnitude and directions over time for incidence and mortality of GCAYA were analysed and compared among four countries. MAIN OUTCOMES AND MEASURES: Outcomes included new cases, deaths, mortality-to-incidence ratios (MIRs), disability-adjusted life years, and their age-standardised rates and estimated annual percentage changes (AAPCs).
resultsThere were 49 008 new cases and 27 895 deaths from GCAYA in 2019, nearly half of which occurred in China. The AAPCs for the age-standardised incidence and mortality rate were 0.3 (-0.1 to 0.7), -3.6 (-3.7 to -3.4), -3.2 (-3.8 to -2.6), -0.1 (-0.6 to 0.5) and -2.0 (-2.3 to -1.6), -5.6 (-6.2 to -5.0), -4.4 (-4.7 to -4.1), -0.7 (-1.0 to -0.3) in China, South Korea, Japan and the USA, respectively. The incidence rate for females in the USA rose by 0.4% annually. GC ranks fifth, first, fourth and ninth in China, South Korea, Japan and the USA regarding burdens caused by cancer in adolescents and young adults. The MIRs declined constantly in South Korea and China, and the MIR in the USA became the highest in 2019.
conclusionsAlthough not covered by prevention and screening programmes, variations in disease burden and time trends may reflect variations in risk factors, cancer control strategies and treatment accessibility of GC among the four countries. Investigating the reasons behind the varying disease burden and changing trends of GCAYA across countries will inform recommendations for prevention measures and timely diagnosis specific to this underserved population to further decrease the GC burden.
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