Trial reportOphthalmology. Glaucoma
The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.
Trial report in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03267849 (Lamina Cribrosa Depth Change With Change in Eye Pressure), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lamina Cribrosa Depth Change With Change in Eye Pressure
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticity.Biomechanics and modeling in mechanobiology · 2026Article
- Article
- Digital Volume Correlation Challenge 2.0: A Comprehensive Dataset for Digital Volume Correlation Benchmarking.Research square · 2026Article
- Evaluation of Changes in Ocular Tissue Elasticity Before and After Trabeculectomy Using Shear Wave Elastography.Journal of clinical medicine · 2026Article
- Deep learning method for semi-automated segmentation of optic nerve head tissues in optical coherence tomography images.Experimental eye research · 2025Article
- Deformation Response of the Human Lamina Cribrosa to Intracranial Pressure Lowering.Journal of biomechanical engineering · 2025Article
- Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering.Journal of biomechanical engineering · 2025Article
- The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients.Translational vision science & technology · 2024Article
- Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors.Progress in retinal and eye research · 2024Review
- Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors.Investigative ophthalmology & visual science · 2023Article
- Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models.Investigative ophthalmology & visual science · 2023Article
- Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head.Investigative ophthalmology & visual science · 2022Article
- Digital volume correlation for the characterization of musculoskeletal tissues: Current challenges and future developments.Frontiers in bioengineering and biotechnology · 2022Review
- Long-term Remodeling Response in the Lamina Cribrosa Years after Intraocular Pressure Lowering by Suturelysis after Trabeculectomy.Ophthalmology. GlaucomaArticle
- A Noninvasive Clinical Method to Measure in Vivo Mechanical Strains of the Lamina Cribrosa by OCT.Ophthalmology scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo measure biomechanical strains in the lamina cribrosa (LC) of living human eyes with intraocular pressure (IOP) lowering.
designCohort study.
participantsPatients with glaucoma underwent imaging before and after laser suturelysis after trabeculectomy surgery (29 image pairs; 26 persons).
interventionNoninvasive imaging of the eye.
main outcome measuresStrains in optic nerve head tissue and changes in depths of the anterior border of the LC.
resultsIntraocular pressure decreases caused the LC to expand in thickness in the anterior-posterior strain (E
conclusionsWith IOP lowering, the LC moves either into or out of the eye but, on average, expands in thickness and contracts in radius. Shear strains are nearly as substantial as in-plane strains. Biomechanical strains are more compliant in eyes with greater glaucoma damage. This work was registered at ClinicalTrials.gov as NCT03267849.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.