ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Centering the Needs of Transgender, Nonbinary, and Gender-Diverse Populations in Neuroendocrine Models of Gender-Affirming Hormone Therapy.
Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- No impact of sex or testosterone treatment on wheel running in a rat model of inflammatory bowel disease.Biology of sex differences · 2026Article
- Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis.Advanced biology · 2026Article
- Queering Studies of Health and Bodily Experience: An Example From the Transgender Resilience and Health Study.American journal of biological anthropology · 2025Article
- Short and long duration testosterone treatments induce reversable subfertility in female mice using a gestational model of gender-affirming hormone therapy.Human reproduction (Oxford, England) · 2025Article
- The Potential Health Risks and Benefits of Progesterone in the Transgender Woman Population-A Narrative Review.Journal of clinical medicine · 2024Review
- A Mouse Model to Investigate the Impact of Gender Affirming Hormone Therapy with Estradiol on Reproduction.Advanced biology · 2024Article
- Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology.Hormones and behavior · 2024Article
- Epigenetic mechanisms underlying sex differences in the brain and behavior.Trends in neurosciences · 2024Review
- Using Animal Models for Gender-Affirming Hormone Therapy.Journal of the Endocrine Society · 2023Article
- Sex differences in dominance relationships in Syrian hamsters.Physiology & behavior · 2023Article
- Importance of survey demographic questions to foster inclusion in medicine and research and reduce health inequities for LGBTQIA2S+ individuals.American journal of physiology. Heart and circulatory physiology · 2023Article
- Perspective on equitable translational studies and clinical support for an unbiased inclusion of the LGBTQIA2S+community.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Exposomics as a tool to investigate differences in health and disease by sex and gender.Exposome · 2023Review
- Diversity, Equity, and Inclusivity in Biological Psychiatry Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
Most studies attempting to address the health care needs of the millions of transgender, nonbinary, and/or gender-diverse (TNG) individuals rely on human subjects, overlooking the benefits of translational research in animal models. Researchers have identified many ways in which gonadal steroid hormones regulate neuronal gene expression, connectivity, activity, and function across the brain to control behavior. However, these discoveries primarily benefit cisgender populations. Research into the effects of exogenous hormones such as estradiol, testosterone, and progesterone has a direct translational benefit for TNG individuals on gender-affirming hormone therapies (GAHTs). Despite this potential, endocrinological health care for TNG individuals remains largely unimproved. Here, we outline important areas of translational research that could address the unique health care needs of TNG individuals on GAHT. We highlight key biomedical questions regarding GAHT that can be investigated using animal models. We discuss how contemporary research fails to address the needs of GAHT users and identify equitable practices for cisgender scientists engaging with this work. We conclude that if necessary and important steps are taken to address these issues, translational research on GAHTs will greatly benefit the health care outcomes of TNG people.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.