Evidence map›Paper›PMID 35863509›Full record

ReviewThe Journal of allergy and clinical immunology2022

TSLP, IL-33, and IL-25: Not just for allergy and helminth infection.

Alison G Stanbery, Shuchi Smita, Jakob von Moltke, Elia D Tait Wojno, Steven F Ziegler

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026
    Review
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  10. Article
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  16. Platelet-mast cell dialogue in innate immune response and inflammation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  17. Review
  18. Review
  19. IL-33 Elicits LTCEuropean journal of immunology · 2026
    Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alison G StanberyDepartment of Immunology, University of Washington, Seattle, Wash.
Shuchi SmitaDepartment of Immunology, University of Washington, Seattle, Wash.
Jakob von MoltkeDepartment of Immunology, University of Washington, Seattle, Wash.
Elia D Tait WojnoDepartment of Immunology, University of Washington, Seattle, Wash.
Steven F ZieglerDepartment of Immunology, University of Washington, Seattle, Wash; Benaroya Research Institute, Seattle, Wash. Electronic address: sziegler@benaroyaresearch.org.
University of Washington · US

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, Anna Karolina Palucka · 2019 to 2026
$23.1M
Regulation of the Innate Immune Response by the Epithelium in AsthmaU19AI125378 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HALLSTRAND, TEAL S · 2016 to 2020
$9.2M
TSLP and the Pathophysiology of AsthmaR01AI068731 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2006 to 2016
$4.5M
Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodelingR01AI163160 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JASON S DEBLEY · 2022 to 2026
$4.3M
Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine.R01AI130379 · NIAID · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2017 to 2026
$3.5M
IL-33 and food allergyR01AI124220 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2016 to 2020
$3.0M
Tuft cell effector functions in the small intestineR01AI145848 · NIAID · UNIVERSITY OF WASHINGTON · PI VON MOLTKE, JAKOB H. · 2020 to 2024
$2.8M
Regulation of the tuft-ILC2 circuit in the small intestineR01AI167923 · NIAID · UNIVERSITY OF WASHINGTON · PI Jakob H. von Moltke · 2022 to 2026
$2.8M
The Notch Signaling Pathway Regulates Basophil Responses During Helminth InfectionR01AI132708 · NIAID · UNIVERSITY OF WASHINGTON · PI TAIT WOJNO, ELIA D · 2017 to 2021
$2.1M
Tuft Cell Effector Functions in the IntestineR37AI145848 · NIAID · UNIVERSITY OF WASHINGTON · PI Jakob H. von Moltke · 2025 to 2026
$1.4M
Regulation of Tfh function in autoimmunity by TSLPR21AI169418 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2022 to 2023
$476k
NIAID NIH HHS R01 AI068731NIAID NIH HHS R01 AI124220NIAID NIH HHS R01 AI130379NIAID NIH HHS R01 AI132708NIAID NIH HHS R01 AI145848NIAID NIH HHS R01 AI163160NIAID NIH HHS R01 AI167923NIAID NIH HHS R21 AI169418NIAID NIH HHS R37 AI145848NIAID NIH HHS U19 AI125378NIAID NIH HHS U19 AI142733
6 · The paper itself

Abstract

The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, thymic stromal lymphopoietin, IL-33, and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms and allergens. In particular, these cytokines activate group 2 innate lymphoid cells, T

Indexed as

HelminthiasisHypersensitivityInterleukin-17Interleukin-33Thymic Stromal LymphopoietinHumansImmunity, InnateLymphocytesIL25 protein, humanInterleukin-17Interleukin-33Thymic Stromal LymphopoietinTSLP protein, humanallergycancerCytokineshelminthtissue immunityviral infection

Identifiers

PMID35863509
PMCPMC9742339
OpenAlexW4285808873

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.