Evidence map›Paper›PMID 35863324›Full record

ArticleCell systems2022

The need for speed: Migratory cells in tight spaces boost their molecular clock.

Dhananjay Bhaskar, Alex M Hruska, Ian Y Wong

Abstract readComment
In one paragraph

Article in Cell systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Dhananjay BhaskarSchool of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA.
Alex M HruskaSchool of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA.
Ian Y WongSchool of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA. Electronic address: ian_wong@brown.edu.

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI WONG, IAN Y · 2016 to 2025
$22.6M
Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell MigrationR01GM140108 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUO, MING, WONG, IAN Y · 2021 to 2025
$2.3M
NIGMS NIH HHS P20 GM109035NIGMS NIH HHS R01 GM140108
6 · The paper itself

Abstract

Cells migrating in spatial confinement exhibit higher intracellular calcium levels, which increases the oscillation frequency of a "molecular clock" that synchronizes guanine nucleotide exchange factor GEF-H1 and microtubule polymerization for more frequent bursts of speed.

Indexed as

MicrotubulesRho Guanine Nucleotide Exchange FactorsRho Guanine Nucleotide Exchange Factors

Identifiers

PMID35863324
PMCPMC10071288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.