Evidence map›Paper›PMID 35863004›Full record

ArticleMicrobiology spectrum2022

Alterations of the Gut Microbiota in Patients with Diabetic Nephropathy.

Lili Zhang, Zhisheng Wang, Xiaona Zhang, Lu Zhao, Jinjin Chu, Haibo Li, Wenchang Sun, Chunjuan Yang, Hui Wang, Wenqing Dai and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Nutrients · 2026
    Article
  18. Article
  19. Characterization of gut microbiota in patients with diabetic kidney disease.Frontiers in cellular and infection microbiology · 2026
    Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lili ZhangDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.ORCID 0000-0002-4616-2529
Zhisheng WangDepartment of Neurosurgery, Sunshine Union Hospital, Weifang, China.
Xiaona ZhangDepartment of Endocrinology, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Lu ZhaoDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Jinjin ChuDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Haibo LiDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Wenchang SunDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Chunjuan YangDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Hui WangDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Wenqing DaiDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Shushan YanDepartment of General Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, China.
Xiaohua ChenDepartment of Nuclear Medicine, The First Affiliated Hospital of Weifang Medical University, Weifang, China.
Donghua XuDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University, Weifang, China.ORCID 0000-0002-9146-7858
Weifang Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is the primary cause of end-stage renal disease. Accumulating studies have implied a critical role for the gut microbiota in diabetes mellitus (DM) and DN. However, the precise roles and regulatory mechanisms of the gut microbiota in the pathogenesis of DN remain largely unclear. In this study, metagenomics sequencing was performed using fecal samples from healthy controls (CON) and type 2 diabetes mellitus (T2DM) patients with or without DN. Fresh fecal samples from 15 T2DM patients without DN, 15 DN patients, and 15 age-, gender-, and body mass index (BMI)-matched healthy controls were collected. The compositions and potential functions of the gut microbiota were estimated. Although no difference of gut microbiota α and β diversity was observed between the CON, T2DM, and DN groups, the relative abundances of butyrate-producing bacteria (

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesGastrointestinal MicrobiomeBacteroidesEubacterialesHumanscompositiondiabetic nephropathyfunctiongut microbiotametagenomics

Identifiers

PMID35863004
PMCPMC9430528
OpenAlexW4285494903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.