Evidence map›Paper›PMID 35863003›Full record

ArticleMicrobiology spectrum2022

Active Circulation of Corynebacterium ulcerans among Nonhuman Primates.

Archana Thomas, Ariel M Slifka, Sara M Hendrickson, Ian J Amanna, Mark K Slifka

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Up-to-date MALDI-TOF MS-based identification of theJournal of clinical microbiology · 2026
    Article
  2. First isolation of nontoxigenic tox gene-bearing Corynebacterium ulcerans from a diphtheria case in Minas Gerais, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  3. Review
  4. Identification ofmSphere · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Archana ThomasOregon Health & Science University, Beaverton, Oregon, USA.
Ariel M SlifkaOregon Health & Science University, Beaverton, Oregon, USA.
Sara M HendricksonOregon Health & Science University, Beaverton, Oregon, USA.
Ian J AmannaNajit Technologies, Inc., Beaverton, Oregon, USA.
Mark K SlifkaOregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0001-8205-6136
Oregon Health & Science University · USNajít Technologies (United States) · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
An Advanced Vaccine Candidate To Prevent Zika Virus InfectionR01AI132186 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SLIFKA, MARK K · 2017 to 2021
$6.9M
NIAID NIH HHS R01 AI132186NIH HHS P51 OD011092
6 · The paper itself

Abstract

Diphtheria is rare in the United States. and many industrialized nations due to development of an effective vaccine, coupled with high vaccination coverage. Although there is continued risk of importation and transmission of Corynebacterium diphtheriae, C. ulcerans has now become the dominant source of diphtheria cases among several European countries. Bearing this in mind, a better understanding of C. ulcerans biology is clearly needed. Here, we identified active transmission of toxigenic C. ulcerans among indoor- and outdoor-housed rhesus macaques based on diphtheria toxin-specific serology assays as well as direct isolation of C. ulcerans from a recently infected animal. In addition to animal-to-animal transmission, we found serological evidence indicative of potential human transmission. Together, these results provide new details on natural Corynebacterium transmission among nonhuman primates and emphasizes the importance of maintaining high vaccination coverage to reduce the risk of potential zoonotic infection.

Indexed as

DiphtheriaAnimalsCorynebacteriumHumansMacaca mulattaRetrospective StudiesCorynebacteriumdiphtheriaELISAneutralizing antibodiesnonhuman primates

Identifiers

PMID35863003
PMCPMC9431270
OpenAlexW4285091986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.