ArticleMicrobiology spectrum2022
The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries.
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Metal Alloys Used in Dental Prosthetics and Their Impact on the Oral Microbiome: Narrative Review.Dentistry journal · 2026Review
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Association between dental caries and self-reported COPD prevalence in U.S. adults ages ≥ 60-year: a cross-sectional analysis of NHANES 2015-2020.Journal of oral microbiology · 2026Article
- Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries.Journal of translational medicine · 2025Article
- An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection.Cell communication and signaling : CCS · 2025Article
- Advances and challenges in drug design against dental caries: Application ofJournal of pharmaceutical analysis · 2025Review
- The landscape of the microbiome at different stages of root caries.Clinical oral investigations · 2025Article
- Microbiological and toxicity analyses of the synthetic polymer polyhexamethylene guanidine hydrochloride against endodontic microorganisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Sodium houttuyfonate inhibits the cariogenic virulence ofJournal of oral microbiology · 2025Article
- Arginine inhibits cross-kingdom interactions and synergistic cariogenicity betweenFrontiers in cellular and infection microbiology · 2025Article
- Veillonella parvula promotes root caries development through interactions with Streptococcus mutans and Candida albicans.Microbial biotechnology · 2024Article
- Article
- Periodontitis contributes to COPD progression via affecting ferroptosis.BMC oral health · 2023Article
- Efficient Removal of Dental Plaque Biofilm from Training Typodont Teeth via Water Flosser.Bioengineering (Basel, Switzerland) · 2023Article
- The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance inCurrent clinical microbiology reports · 2023Article
- Dual transcriptome ofJournal of oral microbiology · 2023Article
- Extracellular vesicles of Candida albicans regulate its own growth through the L-arginine/nitric oxide pathway.Applied microbiology and biotechnology · 2023Article
- Candida albicans CHK1 gene regulates its cross-kingdom interactions with Streptococcus mutans to promote caries.Applied microbiology and biotechnology · 2022Article
- Natural products from traditional medicine as promising agents targeting at different stages of oral biofilm development.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cross-kingdom interactions between Candida albicans and Actinomyces viscosus play critical roles in root caries. However, the key pathway by which C. albicans regulates its interactions with A. viscosus is unclear. Here, we first employed 39 volunteers with root caries and 37 caries-free volunteers, and found that the abundances of C. albicans and A. viscosus were significantly increased in the individuals with root caries and showed a strong positive correlation. Their dual-species combination synergistically promoted biofilm formation and root caries in rats. The arginine biosynthesis pathway of C. albicans was significantly upregulated in dual-species biofilms and dental plaques from another 10 root caries volunteers compared with the 10 caries-free volunteers. The exogenous addition of arginine increased the cariogenicity of the dual-species biofilm. The C. albicans
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.