Evidence map›Paper›PMID 35862974›Full record

ArticleMicrobiology spectrum2022

Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant

Kasturi Banerjee, Michael P Motley, Camila Boniche-Alfaro, Somanon Bhattacharya, Raj Shah, Andrew Ardizzone, Bettina C Fries

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Co-Occurrence of Resistance to Aminoglycosides and Carbapenems inInternational journal of microbiology · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kasturi Banerjee *Department of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-8803-3602
Michael P Motley *Department of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Camila Boniche-AlfaroDepartment of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Somanon BhattacharyaDepartment of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-8562-3877
Raj ShahDepartment of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Andrew ArdizzoneDepartment of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Bettina C FriesDepartment of Medicine, Infectious Disease Division, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-6847-5518
Stony Brook University · USNorthport VA Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
Studying the role of anti-capsular antibodies in mediating pathogenesis of carbapenem-resistant Klebsiella pneumoniaeF30AI140611 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOTLEY, MICHAEL PETER · 2019 to 2021
$128k
Optimization of therapeutic mAbs to carbapenem resistant Klebsiella clone ST258I01BX003741 · VA · NORTHPORT VA MEDICAL CENTER · PI FRIES, BETTINA · 2019 to 2025
–
BLRD VA I01 BX003741NIAID NIH HHS F30 AI140611NIGMS NIH HHS T32 GM008444
6 · The paper itself

Abstract

The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnimalsAnti-Bacterial AgentsAntibodies, MonoclonalCarbapenemsMacrophagesMiceAnti-Bacterial AgentsAntibodies, MonoclonalCarbapenemsanti-bacterial immunotherapycapsular antibodiescapsular polysaccharidecarbapenem-resistant Klebsiella pneumoniaeclade 1 Klebsiella pneumoniaecross-protectionST258

Identifiers

PMID35862974
PMCPMC9430753
OpenAlexW4285014132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.