Evidence map›Paper›PMID 35862954›Full record

ArticleMicrobiology spectrum2022

The Cell-Cell Communication Signal Indole Controls the Physiology and Interspecies Communication of Acinetobacter baumannii.

Binbin Cui, Xiayu Chen, Quan Guo, Shihao Song, Mingfang Wang, Jingyun Liu, Yinyue Deng

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. From screening to treatment:Microbiology spectrum · 2026
    Article
  3. Transposase-Associated Variation nearPathogens (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. mLife · 2025
    Article
  7. Carnosol attenuatesVirulence · 2025
    Article
  8. A cell-cell communication signal fromApplied and environmental microbiology · 2025
    Article
  9. Article
  10. Indole-3-acetic acid (IAA) protectsApplied and environmental microbiology · 2025
    Article
  11. Article
  12. Signaling inComputational and structural biotechnology journal · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Binbin Cui *School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.
Xiayu Chen *School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.
Quan GuoSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.
Shihao SongSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.
Mingfang WangSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.
Jingyun LiuDepartment of Stomatology, Zhengzhou Shuqing Medical College, Zhenzhou, China.
Yinyue DengSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen Universitygrid.12981.33, Sun Yat-sen University, Shenzhen, China.ORCID 0000-0003-1511-0870
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many bacteria utilize quorum sensing (QS) to control group behavior in a cell density-dependent manner. Previous studies have demonstrated that Acinetobacter baumannii employs an N-acyl-L-homoserine lactone (AHL)-based QS system to control biological functions and virulence. Here, we report that indole controls biological functions, virulence and AHL signal production in A. baumannii. The biosynthesis of indole is performed by A1S_3160 (AbiS,

Indexed as

Acinetobacter baumanniiAcyl-ButyrolactonesBacterial ProteinsEscherichia coliHumansIndolesQuorum SensingType III Secretion SystemsAcyl-ButyrolactonesBacterial ProteinsIndolesType III Secretion SystemsAcinetobacter baumanniicompetitive fitnessindolequorum sensingvirulence

Identifiers

PMID35862954
PMCPMC9431217
OpenAlexW4283827945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.