Evidence map›Paper›PMID 35862860›Full record

ArticleOrganic letters2022

Synthesis of Unsymmetrical Vicinal Diamines via Directed Hydroamination.

Byung Joo Lee, Andrew R Ickes, Anil K Gupta, Seth C Ensign, Tam D Ho, Anika Tarasewicz, Evan P Vanable, Gregory D Kortman, Kami L Hull

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Iridium-catalysed hydroamination of internal homoallylic amines.Chemical communications (Cambridge, England) · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Byung Joo LeeDepartment of Chemistry, University of Texas at Austin, 105 E 24th St., Austin, Texas 78712, United States.
Andrew R IckesDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Mathews, Urbana, Illinois 61812, United States.
Anil K GuptaDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Mathews, Urbana, Illinois 61812, United States.
Seth C EnsignDepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Mathews, Urbana, Illinois 61812, United States.
Tam D HoDepartment of Chemistry, University of Texas at Austin, 105 E 24th St., Austin, Texas 78712, United States.
Anika TarasewiczDepartment of Chemistry, University of Texas at Austin, 105 E 24th St., Austin, Texas 78712, United States.
Evan P VanableDepartment of Chemistry and Biochemistry, Elmhust University, 190 Prospect Avenue, Elmhurst, Illinois 60126, United States.
Gregory D KortmanDepartment of Chemistry, University of Texas at Austin, 105 E 24th St., Austin, Texas 78712, United States.
Kami L HullDepartment of Chemistry, University of Texas at Austin, 105 E 24th St., Austin, Texas 78712, United States.ORCID 0000-0003-3102-2686

Funding

Transition Metal-Catalyzed Alkene FunctionalizationR35GM125029 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Kami Lee Hull · 2017 to 2026
$2.7M
NIGMS NIH HHS R35 GM125029
6 · The paper itself

Abstract

Vicinal diamines are a common motif found in biologically active molecules. The hydroamination of allyl amine derivatives is a powerful approach for the synthesis of substituted 1,2-diamines. Herein, the rhodium-catalyzed hydroamination of primary and secondary allylic amines using diverse amine nucleophiles, including primary, secondary, acyclic, and cyclic aliphatic amines to access a wide range of unsymmetrical vicinal diamines, is presented. The utility of this methodology is further demonstrated through the rapid synthesis of several bioactive molecules and analogs.

Indexed as

DiaminesRhodiumAminesCatalysisStereoisomerismAminesDiaminesRhodium

Identifiers

PMID35862860
PMCPMC9757009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.