Evidence map›Paper›PMID 35862809›Full record

ArticlemSystems2022

Forecasting Staphylococcus aureus Infections Using Genome-Wide Association Studies, Machine Learning, and Transcriptomic Approaches.

Mohamed Sassi, Julie Bronsard, Gaetan Pascreau, Mathieu Emily, Pierre-Yves Donnio, Matthieu Revest, Brice Felden, Thierry Wirth, Yoann Augagneur

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Methicillin-sensitiveMicrobial genomics · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Average Nucleotide Identity basedbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mohamed SassiInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Julie BronsardInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Gaetan PascreauInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Mathieu EmilyInstitut Agro, CNRS, Université de Rennes, IRMAR (Institut de Recherche Mathématique de Rennes)-UMR 6625, Rennes, France.
Pierre-Yves DonnioInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Matthieu RevestInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Brice FeldenInserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.
Thierry Wirth *Institut de Systématique, Evolution, Biodiversité (ISYEB), UMR-CNRS 7205, Muséum National d'Histoire Naturelle, Université Pierre et Marie Curie, Université des Antilles, Ecole Pratique des Hautes Etudes, Sorbonne Universités, Paris, France.
Yoann Augagneur *Inserm, BRM (Bacterial Regulatory RNAs and Medicine)-UMR_S 1230, Rennes, France.ORCID 0000-0002-6816-5931
Inserm · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is a major human and animal pathogen, colonizing diverse ecological niches within its hosts. Predicting whether an isolate will infect a specific host and its subsequent clinical fate remains unknown. In this study, we investigated the S. aureus pangenome using a curated set of 356 strains, spanning a wide range of hosts, origins, and clinical display and antibiotic resistance profiles. We used genome-wide association study (GWAS) and random forest (RF) algorithms to discriminate strains based on their origins and clinical sources. Here, we show that the presence of

Indexed as

BacteremiaStaphylococcal InfectionsAnimalsGenome-Wide Association StudyHumansMachine LearningRNAStaphylococcus aureusTranscriptomeRNAbacteremiacoding and noncoding regionsgenetic markersgenomicsGWASnasal colonizationrandom forestStaphylococcus aureustrancriptomics

Identifiers

PMID35862809
PMCPMC9426533
OpenAlexW4283817160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.