Evidence map›Paper›PMID 35862773›Full record

ArticlemBio2022

A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry.

Liangqin Tong, Lin Wang, Shumin Liao, Xiaoping Xiao, Jing Qu, Chunli Wu, Yibin Zhu, Wanbo Tai, Yanhong Huang, Penghua Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Liangqin Tong *Tsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.
Lin Wang *Tsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.
Shumin Liao *Department of Otolaryngology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Xiaoping XiaoTsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.
Jing QuInstitute of Pathogenic Organisms, Shenzhen Center for Disease Control and Preventiongrid.464443.5, Shenzhen, Guangdong, China.
Chunli WuInstitute of Pathogenic Organisms, Shenzhen Center for Disease Control and Preventiongrid.464443.5, Shenzhen, Guangdong, China.
Yibin ZhuTsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.
Wanbo TaiInstitute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Yanhong HuangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Penghua WangDepartment of Immunology, School of Medicine, the University of Connecticut Health Center, Farmington, Connecticut, USA.
Liang LiDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Renli ZhangInstitute of Pathogenic Organisms, Shenzhen Center for Disease Control and Preventiongrid.464443.5, Shenzhen, Guangdong, China.
Ye XiangTsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.
Gong ChengTsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua Universitygrid.12527.33, Beijing, China.ORCID 0000-0001-7447-5488
Center for Life Sciences · CNShenzhen Bay Laboratory · CNShenzhen Center for Disease Control and Prevention · CNSouthern University of Science and Technology · CNSun Yat-sen University · CNUConn Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the global pandemic and life-threatening coronavirus disease 2019 (COVID-19). Although vaccines and therapeutic antibodies are available, their efficacy is continuously undermined by rapidly emerging SARS-CoV-2 variants. Here, we found that all-

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Angiotensin-Converting Enzyme 2Antiviral AgentsHumansPeptidyl-Dipeptidase AProtein BindingSpike Glycoprotein, CoronavirusTretinoinVitamin AAngiotensin-Converting Enzyme 2Antiviral AgentsPeptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TretinoinVitamin Aall-trans retinoic acidcellular entrySARS-CoV-2structural mechanism

Identifiers

PMID35862773
PMCPMC9426596
OpenAlexW4285086881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.