Evidence map›Paper›PMID 35862770›Full record

ArticlemBio2022

Defining the Genes Required for Survival of Mycobacterium bovis in the Bovine Host Offers Novel Insights into the Genetic Basis of Survival of Pathogenic Mycobacteria.

Amanda J Gibson, Jennifer Stiens, Ian J Passmore, Valwynne Faulkner, Josephous Miculob, Sam Willcocks, Michael Coad, Stefan Berg, Dirk Werling, Brendan W Wren and 3 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Comparative transcriptomic signatures of virulent and attenuatedFrontiers in cellular and infection microbiology · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Amanda J Gibson *Centre for Emerging, Endemic and Exotic Diseases, Pathobiology and Population Sciences, Royal Veterinary Collegegrid.20931.39, Hatfield, United Kingdom.
Jennifer Stiens *Institute of Structural and Molecular Biology, Biological Sciences, Birkbeck, University of London, London, United Kingdom.
Ian J PassmoreLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Valwynne FaulknerCentre for Emerging, Endemic and Exotic Diseases, Pathobiology and Population Sciences, Royal Veterinary Collegegrid.20931.39, Hatfield, United Kingdom.
Josephous MiculobCentre for Emerging, Endemic and Exotic Diseases, Pathobiology and Population Sciences, Royal Veterinary Collegegrid.20931.39, Hatfield, United Kingdom.
Sam WillcocksLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Michael CoadAnimal and Plant Health Agencygrid.422685.f, Addlestone, Surrey, United Kingdom.
Stefan BergAnimal and Plant Health Agencygrid.422685.f, Addlestone, Surrey, United Kingdom.
Dirk WerlingCentre for Emerging, Endemic and Exotic Diseases, Pathobiology and Population Sciences, Royal Veterinary Collegegrid.20931.39, Hatfield, United Kingdom.
Brendan W WrenLondon School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0002-6140-9489
Irene NobeliInstitute of Structural and Molecular Biology, Biological Sciences, Birkbeck, University of London, London, United Kingdom.
Bernardo Villarreal-RamosAnimal and Plant Health Agencygrid.422685.f, Addlestone, Surrey, United Kingdom.
Sharon L KendallCentre for Emerging, Endemic and Exotic Diseases, Pathobiology and Population Sciences, Royal Veterinary Collegegrid.20931.39, Hatfield, United Kingdom.ORCID 0000-0003-3277-3035
Royal Veterinary College · GBAnimal and Plant Health Agency · GBLondon School of Hygiene & Tropical Medicine · GBInstitute of Structural and Molecular Biology · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N004590/1
6 · The paper itself

Abstract

Tuberculosis has severe impacts on both humans and animals. Understanding the genetic basis of survival of both Mycobacterium tuberculosis, the human-adapted species, and Mycobacterium bovis, the animal-adapted species, is crucial to deciphering the biology of both pathogens. There are several studies that identify the genes required for survival of M. tuberculosis

Indexed as

Mycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis, BovineAnimalsCattleCholesterolHumansMiceVirulence FactorsCholesterolVirulence Factorsgene essentialityOne HealthTn-seqtuberculosisvirulence factors

Identifiers

PMID35862770
PMCPMC9426507
OpenAlexW4285495645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.