ArticlemBio2022
Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 39 citations in OpenAlex.
- Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus.Science advances · 2026Article
- Updated A(H1N1)pdm09 influenza virus ferret infection model permits refined antiviral assessment using aerosol inhalation challenge.PLoS pathogens · 2026Article
- Limited 'heft' of weight-based outcomes in predicting influenza A virus disease severity in ferrets.PLoS computational biology · 2026Article
- Lack of respiratory droplet transmission of two recent human influenza A(H5N1) viruses in female ferrets.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026Article
- Defining the transmissible dose 50% for two pandemic influenza viruses in ferrets.Journal of virology · 2026Article
- Immunity to hemagglutinin and neuraminidase results in additive reductions in airborne transmission of influenza H1N1 virus in ferrets.Science advances · 2026Article
- Exposure route drives SARS-CoV-2 infection patterns in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Advancing A(H5N1) influenza risk assessment in ferrets through comparative evaluation of airborne virus shedding patterns.Nature communications · 2026Article
- Paired versus Single Housing of Ferrets (Mustela putorius furo) Does Not Influence Experimental Outcomes of Influenza A Virus Pathogenesis Studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Efficient airborne transmission of influenza D virus in ferret models and serological evidence of human exposure in Northeast China.Emerging microbes & infections · 2025Article
- Bioluminescent reporter influenza A viruses to track viral infections.Microbiology spectrum · 2025Article
- Identification of clinical and virological correlates associated with influenza A candidate vaccine virus (CVV) attenuation in a ferret model.Journal of virology · 2025Article
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- Review
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- Establishment and validation of a ferret model for systemic antibiotic treatment during influenza A virus infection.Lab animal · 2025Article
- Pandemic risk stemming from the bovine H5N1 outbreak: an account of the knowns and unknowns.Journal of virology · 2025Review
- Eleven quick tips to unlock the power of in vivo data science.PLoS computational biology · 2025Article
- Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models.Emerging microbes & infections · 2024Article
- The highly pathogenic H5N1 virus found in U.S. dairy cattle has some characteristics that could enhance infection and transmission among mammals.Lab animal · 2024Article
Corrections and comments
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Authors and funding
21 authors at 12 institutions in 6 countries.
Funding
Abstract
Past pandemic influenza viruses with sustained human-to-human transmissibility have emerged from animal influenza viruses. Employment of experimental models to assess the pandemic risk of emerging zoonotic influenza viruses provides critical information supporting public health efforts. Ferret transmission experiments have been utilized to predict the human-to-human transmission potential of novel influenza viruses. However, small sample sizes and a lack of standardized protocols can introduce interlaboratory variability, complicating interpretation of transmission experimental data. To assess the range of variation in ferret transmission experiments, a global exercise was conducted by 11 laboratories using two common stock H1N1 influenza viruses with different transmission characteristics in ferrets. Parameters known to affect transmission were standardized, including the inoculation route, dose, and volume, as well as a strict 1:1 donor/contact ratio for respiratory droplet transmission. Additional host and environmental parameters likely to affect influenza transmission kinetics were monitored and analyzed. The overall transmission outcomes for both viruses across 11 laboratories were concordant, suggesting the robustness of the ferret model for zoonotic influenza risk assessment. Among environmental parameters that varied across laboratories, donor-to-contact airflow directionality was associated with increased transmissibility. To attain high confidence in identifying viruses with moderate to high transmissibility or low transmissibility under a smaller number of participating laboratories, our analyses support the notion that as few as three but as many as five laboratories, respectively, would need to independently perform viral transmission experiments with concordant results. This exercise facilitates the development of a more homogenous protocol for ferret transmission experiments that are employed for the purposes of risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.