Evidence map›Paper›PMID 35862755›Full record

ArticleAntimicrobial agents and chemotherapy2022

Increased Innate Immune Susceptibility in Hyperpigmented Bacteriophage-Resistant Mutants of Pseudomonas aeruginosa.

Nitasha D Menon, Samuel Penziner, Elizabeth T Montaño, Raymond Zurich, David T Pride, Bipin G Nair, Geetha B Kumar, Victor Nizet

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Journal of bacteriology · 2026
    Article
  3. Isolation and Genomic Characterization of LyticLife (Basel, Switzerland) · 2026
    Article
  4. AFrontiers in microbiology · 2026
    Article
  5. Review
  6. Article
  7. Genomic insights into drug resistance and virulence determinants in rare pyomelanin-producing clinical isolates of Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Diversification ofMicroorganisms · 2024
    Article
  13. Review
  14. Mutation ofMicrobiology spectrum · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Phage-resistantFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nitasha D MenonSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, India.
Samuel PenzinerDivision of Infectious Diseases and Global Public Health, Department of Medicine, UC San Diego, La Jolla, California, USA.ORCID 0000-0003-0010-9746
Elizabeth T MontañoDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.
Raymond ZurichDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.
David T PrideDivision of Infectious Diseases and Global Public Health, Department of Medicine, UC San Diego, La Jolla, California, USA.ORCID 0000-0001-8161-6015
Bipin G NairSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, India.
Geetha B KumarSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, India.ORCID 0000-0002-4584-6929
Victor NizetDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA.ORCID 0000-0003-3847-0422
University of California San Diego · USTata Institute for Genetics and Society · IN

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
NIAID NIH HHS R01 AI145310NIAID NIH HHS R37 AI052453NIAID NIH HHS T32 AI007036NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Bacteriophage (phage) therapy is an alternative to traditional antibiotic treatments that is particularly important for multidrug-resistant pathogens, such as Pseudomonas aeruginosa. Unfortunately, phage resistance commonly arises during treatment as bacteria evolve to survive phage predation. During

Indexed as

BacteriophagesPseudomonas InfectionsPseudomonas PhagesAnimalsAnti-Bacterial AgentsColistinHumansHydrogen PeroxideImmunity, InnateMicePseudomonas aeruginosaAnti-Bacterial AgentsColistinHydrogen Peroxidebacteriophage resistancebacteriophage therapyinnate immunityPseudomonas aeruginosapyomelanin

Identifiers

PMID35862755
PMCPMC9380547
OpenAlexW4283829908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.