Evidence map›Paper›PMID 35862720›Full record

ArticleInfection and immunity2022

Expression of CD117 (c-Kit) on Circulating B Cells in Pediatric Schistosomiasis.

Isaac O Onkanga, Rachael Hamilton, Pauline N M Mwinzi, Thomas Schneider, Bartholomew N Ondigo, Huldah Sang, Edna Ondari, Fredrick Rawago, Walter Jaoko, Maurice R Odiere and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Isaac O OnkangaCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Rachael HamiltonElegance Biotechnologies, LLC, Wayne, Pennsylvania, USA.
Pauline N M MwinziCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Thomas SchneiderElegance Biotechnologies, LLC, Wayne, Pennsylvania, USA.
Bartholomew N OndigoCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Huldah SangCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Edna OndariCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Fredrick RawagoCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Walter JaokoKAVI-Institute of Clinical Research, and Department of Medical Microbiology & Immunology, University of Nairobigrid.10604.33, Kenya.
Maurice R OdiereCenter for Global Health Research, Kenya Medical Research Institutegrid.33058.3d, Kisumu, Kenya.
Lisa Ganley-LealElegance Biotechnologies, LLC, Wayne, Pennsylvania, USA.ORCID 0000-0002-9566-1041
Kenya Medical Research Institute · KEUniversity of Nairobi · KEEgerton University · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few B cells express CD27, the primary marker for memory B cells, in pediatric schistosomiasis, suggesting B cell malfunction. This study further demonstrates unexpected high expression of CD117 on circulating B cells in children highly exposed to Schistosoma mansoni infectious larvae. CD117 is expressed by immature or lymphoma B cells, but not by mature, circulating cells. We therefore sought to define the significance of CD117 on blood B cells. We found that CD117-positive (CD117

Indexed as

Proto-Oncogene Proteins c-kitSchistosomiasis mansoniB-LymphocytesBone MarrowHumansLymphocyte ActivationProto-Oncogene Proteins c-kitB cellsCD117CD23pediatric schistosomiasisschistosomiasis

Identifiers

PMID35862720
PMCPMC9387214
OpenAlexW4283833532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.