Evidence map›Paper›PMID 35862650›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Novel method for kinetic analysis applied to transport by the uniporter OCT2.

Stephen H Wright, Timothy W Secomb

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. IsMetabolites · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephen H WrightDepartment of Physiology, College of Medicine, University of Arizona, Tucson, Arizona.ORCID 0000-0002-0591-0017
Timothy W SecombDepartment of Physiology, College of Medicine, University of Arizona, Tucson, Arizona.ORCID 0000-0002-0176-5502
University of Arizona · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
Improving In Vitro-In Vivo Extrapolation for Renal Cationic Drug TransportR01GM129777 · NIGMS · UNIVERSITY OF ARIZONA · PI WRIGHT, STEPHEN H · 2018 to 2019
$614k
NIEHS NIH HHS P30 ES006694NIGMS NIH HHS R01 GM129777
6 · The paper itself

Abstract

The kinetics of solute transport shed light on the roles these processes play in cellular physiology, and the absolute values of the kinetic parameters that quantitatively describe transport are increasingly used to model its impact on drug clearance. However, accurate assessment of transport kinetics is challenging. Although most carrier-mediated transport is adequately described by the Michaelis-Menten equation, its use presupposes that the rates of uptake used in the analysis of maximal rates of transport (

Indexed as

WaterAnimalsBiological TransportCHO CellsCricetinaeCricetulusKineticsWaterkineticsmodelorganic cationproximal tubuletransport

Identifiers

PMID35862650
PMCPMC9423780
OpenAlexW4286495482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.