Evidence map›Paper›PMID 35862649›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.

Sethu M Madhavan, Martha Konieczkowski, Leslie A Bruggeman, Megan DeWalt, Jane K Nguyen, John F O'Toole, John R Sedor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Whole Blood Transcriptomic Analysis of Sickle Cell Trait.European journal of haematology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sethu M MadhavanDepartment of Medicine, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-0528-7333
Martha KonieczkowskiMetroHealth Medical Center, Cleveland, Ohio.
Leslie A BruggemanDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0001-5874-705X
Megan DeWaltDepartment of Medicine, The Ohio State University, Columbus, Ohio.
Jane K NguyenDepartment of Pathology, Cleveland Clinic, Cleveland, Ohio.
John F O'TooleDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
John R SedorDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.ORCID 0000-0002-6780-9168
Cleveland Clinic · USThe Ohio State University · USMetroHealth · US

Funding

CWRU NEPHROLOGY TRAINING PROGRAMT32DK007470 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI SEDOR, JOHN R. · 1986 to 2019
$2.9M
Mechanisms of Glomerular ScarringR01DK064719 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI SEDOR, JOHN R. · 2003 to 2006
$1.2M
Apolipoprotein L1 Interaction with SNARE Proteins in the Pathogenesis of Chronic Kidney DiseaseK08DK123411 · NIDDK · OHIO STATE UNIVERSITY · PI MADHAVAN, SETHU MADHAVAN · 2020 to 2024
$805k
NIDDK NIH HHS K08 DK123411NIDDK NIH HHS R01 DK064719NIDDK NIH HHS T32 DK007470
6 · The paper itself

Abstract

Wilms' tumor interacting protein (Wtip) has been implicated in cell junction assembly and cell differentiation and interacts with proteins in the podocyte slit diaphragm, where it regulates podocyte phenotype. To define Wtip expression and function in the kidney, we created a

Indexed as

Kidney DiseasesPodocytesWilms TumorAnimalsCo-Repressor ProteinsCytoskeletal ProteinsFemaleGlomerular Filtration BarrierGuanine Nucleotide Exchange FactorsHumansKidney GlomerulusMicePregnancyProteinuriaCo-Repressor ProteinsCytoskeletal ProteinsGuanine Nucleotide Exchange FactorsWTIP protein, humangene trapglomerular injuryWilms’ tumor interacting protein

Identifiers

PMID35862649
PMCPMC9394782
OpenAlexW4286496632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.