Evidence map›Paper›PMID 35862575›Full record

ArticlePediatric hematology and oncology2023

Epigenetic age acceleration among survivors of pediatric medulloblastoma and primitive neuroectodermal tumor.

Rachel D Harris, Melissa A Richard, Maria Monica J Gramatges, Kevin Wilhelm, Michael E Scheurer, Philip J Lupo, Austin L Brown

Open access · greenAbstract read
In one paragraph

Article in Pediatric hematology and oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rachel D HarrisDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.
Melissa A RichardDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.
Maria Monica J GramatgesDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0947-104X
Kevin WilhelmDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.
Michael E ScheurerDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-8379-6088
Philip J LupoDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-0978-5863
Austin L BrownDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5802-5073
Baylor College of Medicine · US

Funding

Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7M
Integrative Molecular Epidemiology of Neurocognitive Outcomes in Acute Lymphoblastic LeukemiaK07CA218362 · NCI · BAYLOR COLLEGE OF MEDICINE · PI BROWN, AUSTIN L · 2018 to 2022
$758k
NCI NIH HHS K07 CA218362NIEHS NIH HHS P30 ES030285
6 · The paper itself

Abstract

Survivors of childhood central nervous system (CNS) tumors experience early-onset aging-related phenotypes. DNA methylation (DNAm) age is an emerging epigenetic biomarker of physiologic age and may be predictive of chronic health conditions in long-term survivors. This report describes the course of epigenetic age acceleration using post-diagnosis blood samples (median: 3.9 years post-diagnosis; range: 0.04-15.96) from 83 survivors of pediatric CNS tumors. Epigenetic age acceleration was detected in 72% of patients, with an average difference between chronologic and DNAm age of 2.58 years (95% CI: 1.75-3.41,

Indexed as

Central Nervous System NeoplasmsCerebellar NeoplasmsMedulloblastomaNeuroectodermal Tumors, PrimitiveEpigenesis, GeneticHumansSurvivorsagingEpigeneticsmedulloblastomaPNETsurvivorship

Identifiers

PMID35862575
PMCPMC10702578
OpenAlexW4286493364

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.