ArticleProceedings of the National Academy of Sciences of the United States of America2022
fMRI spectral signatures of sleep.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 60 citations in OpenAlex.
- Sleep and Drug Use: Neuroimaging Evidence for a Multidimensional Brain Framework.Biological psychiatry · 2026Review
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Article
- A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness.bioRxiv : the preprint server for biology · 2026Article
- Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Cerebral and Peripheral Hemodynamics Across Wakefulness and NREM Sleep.Journal of sleep research · 2026Article
- A principal component entropy metric for assessing global synchronicity in EEG signals.Scientific reports · 2026Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- Shifts in brain dynamics and drivers of consciousness state transitions.Frontiers in computational neuroscience · 2026Article
- Human brain zero: uncovering the lowest neural state for consciousness engineering.Frontiers in neuroscience · 2026Article
- Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.Nature communications · 2025Article
- Sleep neuroimaging: Review and future directions.Journal of sleep research · 2025Review
- Cortical hierarchy underlying homeostatic sleep pressure alleviation.Nature communications · 2025Article
- Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep.Nature communications · 2025Article
- Functional MRI signals as fast as 1Hz are coupled to brain states and predict spontaneous neural activity.bioRxiv : the preprint server for biology · 2025Article
- Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study.PLoS computational biology · 2025Article
- Amplitude fluctuations of cerebrovascular oscillations and CSF movement desynchronize during NREM3 sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Research square · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 5 countries.
Funding
Abstract
Sleep can be distinguished from wake by changes in brain electrical activity, typically assessed using electroencephalography (EEG). The hallmark of nonrapid-eye-movement (NREM) sleep is the shift from high-frequency, low-amplitude wake EEG to low-frequency, high-amplitude sleep EEG dominated by spindles and slow waves. Here we identified signatures of sleep in brain hemodynamic activity, using simultaneous functional MRI (fMRI) and EEG. We found that, at the transition from wake to sleep, fMRI blood oxygen level-dependent (BOLD) activity evolved from a mixed-frequency pattern to one dominated by two distinct oscillations: a low-frequency (<0.1 Hz) oscillation prominent in light sleep and correlated with the occurrence of spindles, and a high-frequency oscillation (>0.1 Hz) prominent in deep sleep and correlated with the occurrence of slow waves. The two oscillations were both detectable across the brain but exhibited distinct spatiotemporal patterns. During the falling-asleep process, the low-frequency oscillation first appeared in the thalamus, then the posterior cortex, and lastly the frontal cortex, while the high-frequency oscillation first appeared in the midbrain, then the frontal cortex, and lastly the posterior cortex. During the waking-up process, both oscillations disappeared first from the thalamus, then the frontal cortex, and lastly the posterior cortex. The BOLD oscillations provide local signatures of spindle and slow wave activity. They may be employed to monitor the regional occurrence of sleep or wakefulness, track which regions are the first to fall asleep or wake up at the wake-sleep transitions, and investigate local homeostatic sleep processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.