Evidence map›Paper›PMID 35862271›Full record

ArticleACS applied materials & interfaces2022

Advanced Drug Delivery Modulation via Hybrid Nanofibers Enhances Stem Cell Differentiation.

Jeffrey Luo, Letao Yang, Sy-Tsong Dean Chueng, Brian Conley, Christopher Rathnam, Ki-Bum Lee

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeffrey LuoDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-0140-1370
Letao YangDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-0572-9787
Sy-Tsong Dean ChuengDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-1447-5491
Brian ConleyDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.
Christopher RathnamDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0003-3111-4687
Ki-Bum LeeDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-8164-0047
Rutgers, The State University of New Jersey · US

Funding

X-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MARIUZZA, ROY A · 1998 to 2011
$32.2M
UMDNJ TRAINING GRANT IN BIOTECHNOLOGYT32GM008339 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI YARMUSH, MARTIN L · 1989 to 2019
$6.1M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
Machine learning-enabled Comparative Transcriptomic Profiling to Validate NanoScript-induced Inner Ear Hair CellsR01DC016612 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y., LEE, KIBUM · 2018 to 2022
$2.8M
Nanoparticle-based synthetic transcription factor to induce stem cell myogenesisR21AR071101 · NIAMS · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2017 to 2018
$371k
NCRR NIH HHS P41 RR012408NIAMS NIH HHS R21 AR071101NIDCD NIH HHS R01 DC016612NIGMS NIH HHS T32 GM008339NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

Seamlessly integrating soluble factors onto biomedical scaffolds with a precisely manufactured topography for efficient cell control remains elusive since many scaffold fabrication techniques degrade payloads. Surface adsorption of payloads onto synthesized nanoscaffolds retains bioactivity by removing exposure to harsh processing conditions at the expense of inefficient drug loading and uncontrolled release. Herein, we present a nanomaterial composite scaffold paradigm to improve physicochemical surface adsorption pharmacokinetics. As a proof of concept, we integrated graphene oxide (GO) and manganese dioxide (MnO

Indexed as

NanofibersCell DifferentiationManganese CompoundsOsteogenesisOxidesTissue EngineeringTissue ScaffoldsManganese CompoundsOxidesadvanced drug deliveryhybrid nanomaterialsnanoscaffoldsstem cell differentiationtissue engineering

Identifiers

PMID35862271
PMCPMC9357201
OpenAlexW4286494544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.