Evidence map›Paper›PMID 35862221›Full record

ArticleJournal of fish diseases2022

Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis.

Christine Klykken, Lauris Boissonnot, Anne Katrine Reed, Paul Whatmore, Kari Attramadal, Rolf Erik Olsen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fish diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Christine KlykkenAqua Kompetanse AS, Flatanger, Norway.ORCID https://orcid.org/0000-0003-2796-4064
Lauris BoissonnotAqua Kompetanse AS, Flatanger, Norway.
Anne Katrine ReedPharmaq Analytiq AS, Bergen, Norway.
Paul WhatmoreeResearch Department, Queensland Univesity of Technology, Brisbane, QLD, Australia.
Kari AttramadalDepartment of Biotechnology and Food Science, Faculty of Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway.
Rolf Erik OlsenDepartment of Biology, Faculty of Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOPharmaq (Norway) · NOQueensland University of Technology · AU

Funding

Fiskeri - og havbruksnaeringens forskningsfondNorges Forskningsråd
6 · The paper itself

Abstract

Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival.

Indexed as

Fish DiseasesNephrocalcinosisSalmo salarAnimalsGene Expression RegulationTranscriptomeAtlantic salmonkidney malfunctionnephrocalcinosisRNA seq

Identifiers

PMID35862221
PMCPMC9796406
OpenAlexW4286500714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.