ArticleCirculation2022
Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.
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Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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19 citing papers in PubMed, 26 citations in OpenAlex.
- RUNX2 promotes osteoclast differentiation and bone resorption via the newly identified LncRNA-ROD: implications for alveolar remodeling.International journal of oral science · 2026Article
- RNA splicing and cardiovascular disease: a guide for cardiologists.European heart journal · 2026Review
- Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy.Nature communications · 2026Article
- Serum LncRNA PSMB8-AS1 as a novel biomarker for predicting acute coronary syndrome.Scientific reports · 2025Article
- Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function.Cardiovascular research · 2025Article
- Genetics, manifestations, and management of catecholaminergic polymorphic ventricular tachycardia.Current opinion in cardiology · 2025Review
- The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review.Non-coding RNA research · 2025Review
- Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the mFrontiers of medicine · 2025Article
- Endothelial derived, secreted long non-coding RNAsMolecular therapy. Nucleic acids · 2024Article
- Non-Coding RNA-Mediated Gene Regulation in Cardiovascular Disorders: Current Insights and Future Directions.Journal of cardiovascular translational research · 2024Review
- Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects.Nature reviews. Cardiology · 2024Review
- Alternative splicing and related RNA binding proteins in human health and disease.Signal transduction and targeted therapy · 2024Review
- Review
- Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling.iScience · 2023Article
- Cellular reprogramming of fibroblasts in heart regeneration.Journal of molecular and cellular cardiology · 2023Review
- Analysis of Alternative Splicing and Long Noncoding RNAs After the Edwardsiella anguillarum Infected the Immunized European Eels (Anguilla anguilla) Revealed the Role of Outer Membrane Protein A in OmpA Subunit Vaccine.Marine biotechnology (New York, N.Y.) · 2023Article
- Role of ceRNA network in inflammatory cells of rheumatoid arthritis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2023Review
- Natural antisense transcripts as drug targets.Frontiers in molecular biosciences · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Yuanbiao Zhao *Division of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Andrew S Riching *Division of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Walter E Knight *Division of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Congwu Chi *Division of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Lindsey J BroadwellDepartment of Biochemistry (L.J.B.), University of Colorado Boulder.ORCID 0000-0002-7559-3977
Yanmei DuDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Mostafa Abdel-HafizDepartment of Bioengineering (M.A.-H.), University of Colorado Anschutz Medical Campus, Aurora.
Amrut V AmbardekarDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.ORCID 0000-0003-3503-4203
David C IrwinCardiovascular and Pulmonary Research Laboratory, Department of Medicine (D.C.I.), University of Colorado Anschutz Medical Campus, Aurora.
Catherine ProenzaDepartment of Physiology and Biophysics (C.P.), University of Colorado Anschutz Medical Campus, Aurora.
Hongyan XuDepartment of Population Health Sciences, Medical College of Georgia, Augusta University (H.X.).ORCID 0000-0001-7432-9018
Leslie A LeinwandBioFrontiers Institute (L.J.B., L.A.L.), University of Colorado Boulder.ORCID 0000-0003-1470-4810
Lori A WalkerDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Kathleen C WoulfeDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Michael R BristowDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.ORCID 0000-0002-8860-4698
Peter M ButtrickDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.
Kunhua SongDivision of Cardiology, Department of Medicine (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.), University of Colorado Anschutz Medical Campus, Aurora.ORCID 0000-0003-3805-4509
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · USAnna Needs Neuroblastoma Answers · USAugusta University · USNorwegian Womens Public Health Association · NO
Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MPOSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2MRegulation of excitability in sinoatrial myocytesR01HL088427 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI PROENZA, CATHERINE · 2008 to 2024
$5.8MMechanisms for cell signaling in the control of cardiomyogenesisR01HL133230 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Kunhua Song · 2016 to 2026
$4.2MNRSA Training CoreTL1TR002533 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CICUTTO, LISA · 2018 to 2022
$3.0MAllosteric Modulation of HCN ChannelsR01GM140004 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PROENZA, CATHERINE · 2021 to 2024
$1.7MColorado Clinical and Translational Sciences InstituteTL1TR001081 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$1.3MSmall Animal Ultrasound Imager - Vevo 2100S10OD018156 · OD · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., MCKINSEY, TIMOTHY · 2014 to 2014
$506kSex-specific regulation of myofibrillar function in the aging heartK01AG066845 · NIA · UNIVERSITY OF COLORADO DENVER · PI WOULFE, KATHLEEN · 2020 to 2023
$467kNCATS NIH HHS TL1 TR001081NCATS NIH HHS TL1 TR002533NCATS NIH HHS UL1 TR002535NHLBI NIH HHS R01 HL088427NHLBI NIH HHS R01 HL133230NHLBI NIH HHS T32 HL007822NIA NIH HHS K01 AG066845NIDDK NIH HHS P30 DK048520NIGMS NIH HHS R01 GM140004NIH HHS S10 OD018156
Abstract
backgroundAbnormalities in Ca
methodsWe analyzed triadin expression in heart explants from patients with heart failure and cardiac arrhythmias and in hearts from mice carrying a knockout allele for
resultsWe report that
conclusionsThese findings reveal regulation of alternative splicing as a novel mechanism by which a long noncoding RNA controls cardiac function. This study indicates potential therapeutics for heart disease by targeting the long noncoding RNA or pathways regulating alternative splicing.
Indexed as
Alternative SplicingCarrier ProteinsHeart FailureMuscle ProteinsRNA, Long NoncodingAnimalsArrhythmias, CardiacCatecholaminesHeartHumansIn Situ Hybridization, FluorescenceIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMyocytes, CardiacProtein IsoformsCarrier ProteinsCatecholaminesIntracellular Signaling Peptides and ProteinsMuscle ProteinsProtein IsoformsRNA, Long NoncodingRNA Splicing FactorsTRDN protein, humanTrdn protein, mousetriadinarrhythmias, cardiacheart failuremyocytes, cardiacRNA, long noncodingsplicing, alternative
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