Evidence map›Paper›PMID 35861988›Full record

ArticleCirculation. Genomic and precision medicine2022

Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for

Dan Ye, Wei Zhou, Samantha K Hamrick, David J Tester, C S John Kim, Hector Barajas-Martinez, Dan Hu, John R Giudicessi, Charles Antzelevitch, Michael J Ackerman

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dan Ye *Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).ORCID 0000-0003-0619-7070
Wei Zhou *Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).
Samantha K HamrickDepartment of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).ORCID 0000-0002-8680-2906
David J TesterDepartment of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).ORCID 0000-0003-4554-2244
C S John KimDepartment of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).
Hector Barajas-MartinezLankenau Institute for Medical Research, Wynnewood, PA (H.B.-M., C.A.).ORCID 0000-0002-2704-3807
Dan HuLankenau Institute for Medical Research, Wynnewood, PA (H.B.-M., C.A.).ORCID 0000-0002-0994-8434
John R GiudicessiDepartment of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).ORCID 0000-0001-5871-0265
Charles AntzelevitchLankenau Institute for Medical Research, Wynnewood, PA (H.B.-M., C.A.).ORCID 0000-0001-7349-1582
Michael J AckermanDepartment of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory) (D.Y., W.Z., S.K.H., D.J.T., C.S.J.K., J.R.G., M.J.A.).ORCID 0000-0002-8011-3333
Heart Rhythm Society · USLankenau Institute for Medical Research · US

Funding

ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
Development of a whole heart model of the J wave syndromes and novel approaches to pharmacologic management of associated life-threatening arrhythmiasR01HL152201 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES, DI DIEGO, JOSE M. · 2020 to 2023
$2.5M
Novel Approaches to Pharmacologic Management of Life-Threatening Arrhythmias Associated with the J Wave SyndromesR56HL138103 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES · 2018 to 2018
$413k
NHLBI NIH HHS R01 HL047678NHLBI NIH HHS R01 HL152201NHLBI NIH HHS R56 HL138103
6 · The paper itself

Abstract

backgroundThe transient outward current (Ito) that mediates early (phase 1) repolarization is conducted by the

methodsKCND3-V392I was identified in an 18-year-old male with J wave syndrome/early repolarization syndrome, and a history of cardiac arrest including ventricular tachycardia/ventricular fibrillation and atrial fibrillation/atrial flutter. Pathogenic

resultsKCND3-V392I demonstrated a marked gain-of-function phenotype, increasing peak I

conclusionsThis preclinical study provides pharmacological and functional evidence to suggest that Acacetin may be a novel therapeutic for patients with KCND3 gain-of-function-associated J wave syndrome by inhibiting I

Indexed as

Brugada SyndromeFlavonesGain of Function MutationHumansMaleShal Potassium ChannelsVentricular FibrillationacacetinFlavonesKCND3 protein, humanShal Potassium Channelsarrhythmiaautopsyearly repolarization syndromegene mutationion channel

Identifiers

PMID35861988
PMCPMC9588492
OpenAlexW4285040748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.