ArticleCirculation. Cardiovascular imaging2022
Assessment of Device Neoendothelialization With Cardiac Computed Tomography Angiography After Transcatheter Closure of Atrial Septal Defect.
Article in Circulation. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Device endothelialization and morphology assessments at 1 year using computed tomography angiography: comparison of traditional with novel puncturable atrial septal defect occluders.BMC cardiovascular disorders · 2024Trial
- Neovascularization and Neo-Endothelialization After Atrial Septal Defect Closure.JACC. Case reports · 2026Article
- Risk of a residual shunt following patent foramen ovale closure: A myth?Heart international · 2026Article
- Cardiac Computed Tomography in Structural Heart Interventions: From Preprocedural Planning to Procedural Strategy.Reviews in cardiovascular medicine · 2025Review
- Cardiovascular Computed Tomography Angiographic Assessment of Simple Cardiac Shunts in Adults.Reviews in cardiovascular medicine · 2025Review
- Surgical Ventricular Septal Defect Repair.JACC. Case reports · 2025Article
- Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation.PloS one · 2025Article
- Vegetations Lurking in the Dark and the Role of Neoendothelialization.CASE (Philadelphia, Pa.) · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the transcatheter closure of atrial septal defect was established as the treatment of choice several decades ago, the process of device neoendothelialization (NE) in humans is not well understood. We aimed to measure the extent of device NE using cardiac computed tomography angiography and analyze its risk factors.
methodsBetween January 2005 and February 2021, we retrospectively reviewed 164 devices of 112 patients on cardiac computed tomography angiography. We investigated device shape, contrast opacification within the device that differentiated device NE, and device-related thrombosis or vegetation. Risk factor analysis for major adverse cardiovascular events and incomplete NE according to the postprocedural period was performed.
resultsSeventy patients (62.5%) were women, with a median (range) age at the time of device closure of 44.5 (0.6-79.2) years. The mean (±SD) defect size was 16.6 (±7.8) mm, and patients were followed for 35.9±33.9 months. After 6 months of device implantation, 35% of the devices (42/120) had incomplete NE. The intensity of intradevice opacification shifted from complete to partial or nonopacification over time (
conclusionsIncomplete NE of atrial septal defect devices was identified on cardiac computed tomography angiography in significant numbers after 6 months of the procedure. The device diameter was related to incomplete NE and major adverse events. Further prospective and multicenter studies are warranted to validate this new assessment of device NE.
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