Evidence map›Paper›PMID 35861941›Full record

ArticleMedical molecular morphology2022

Expression and clinicopathological significance of glucocorticoid receptor, SGK1, and NDRG1 in hormone-naïve prostate carcinoma.

Shuko Hata, Hiroki Shimada, Naomi Sato, Mayu Koshiishi, Kazue Ise, Tomoaki Ogata, Shinichi Yamashita, Akihiro Ito, Hironobu Sasano, Yasuhiro Nakamura

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Article in Medical molecular morphology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shuko HataDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Hiroki ShimadaDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Naomi SatoDivision of Pathology, Iwate Prefectural Central Hospital, 1-4-1 Ueda Iwate, Morioka, 020-0066, Japan.
Mayu KoshiishiDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Kazue IseDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Tomoaki OgataDivision of Health Administration and Policy, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan.
Shinichi YamashitaDepartment of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Akihiro ItoDepartment of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Hironobu SasanoDepartment of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Yasuhiro NakamuraDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan. yasu-naka@tohoku-mpu.ac.jp.
Tohoku Medical and Pharmaceutical University Hospital · JPTohoku University · JPIwate Prefectural Central Hospital · JP

Funding

Japan Society for the Promotion of Science JP18K06995
6 · The paper itself

Abstract

Glucocorticoid receptor (GR) has been implicated in prostate carcinoma growth and progression. Glucocorticoid receptor beta (GRβ) acts as an inhibitor of GR; however, its function is not well understood. Serum- and glucocorticoid-regulated kinase 1 (SGK1) is a GR-responsive gene that phosphorylates N-myc downstream-regulated gene 1 (NDRG1) and is involved in cancer growth and invasion. However, the expression of GR, GRβ, SGK1, and NDRG1 in prostate cancer and their relationship with clinicopathological and functional significance remain unknown. The association between the status of GR, GRβ, SGK1, and NDRG1 immunoreactivity and clinicopathological variables was analyzed in patients with prostate carcinoma to explore their clinical significance. In prostate carcinoma cases, the relative abundance of GR and NDRG1 immunoreactivity was inversely and significantly associated with the primary tumor stage (pT), while GR immunoreactivity was inversely and significantly associated with the Ki-67 score. The relative expression status of NDRG1 was significantly associated with that of GR. However, no significant correlation was observed between any of the clinicopathological parameters and GRβ and SGK1 expression. Our findings indicate that GR and NDRG1 expression status is correlated with clinicopathological features in patients with prostate cancer.

Indexed as

CarcinomaImmediate-Early ProteinsProstatic NeoplasmsCell Cycle ProteinsGlucocorticoidsHumansIntracellular Signaling Peptides and ProteinsKi-67 AntigenMaleN-myc Downstream-Regulated Gene 1 ProteinProstateProtein Serine-Threonine KinasesReceptors, GlucocorticoidSerum-Glucocorticoid Regulated KinasesCell Cycle ProteinsGlucocorticoidsImmediate-Early ProteinsIntracellular Signaling Peptides and ProteinsKi-67 AntigenN-myc Downstream-Regulated Gene 1 ProteinProtein Serine-Threonine KinasesReceptors, GlucocorticoidSerum-Glucocorticoid Regulated KinasesGlucocorticoid receptor (GR)N-myc down-regulated gene 1 (NDRG1)Primary tumor (pT) stageProstate carcinomaSerum- and glucocorticoid-regulated kinase 1 (SGK1)

Identifiers

PMID35861941
OpenAlexW4286491834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.