ArticleJournal of the American Heart Association2022
Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Jumping on the moon as a potential exercise countermeasure.Experimental physiology · 2026Article
- Blood flow restriction exercise during microgravity exposure in parabolic flight.Experimental physiology · 2026Article
- Blood flow restriction: The acute effects of body tilting and reduced gravity analogues on limb occlusion pressure.Experimental physiology · 2026Article
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Hypogravity simulation using the Variable Gravity Suspension System: A technical report.Experimental physiology · 2026Article
- Cardiovascular response of children to 1 hour of microgravity simulation-a pioneering study.NPJ microgravity · 2026Article
- Cardiovascular response to altered gravity in healthy adults: Insight from graded tilt testing.Physiological reports · 2026Article
- AstroOphthalmology: Basic and Pathophysiological Concepts of Space-Induced Ocular Changes.Eye and brain · 2026Review
- Integrative cardiovascular dose-response to graded lower-body negative pressure.Experimental physiology · 2025Article
- Blunted baroreflex-mediated sympathoinhibition and vasodilation to countdown before exercise in young women compared to men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Effect of simulated microgravity via head-down tilt on intracranial compliance, brain oscillations and cardiovascular autonomic modulation.Scientific reports · 2025Article
- Feasibility and safety of passive orthostatic positioning in mechanically ventilated ICU patients: A prospective observational study.Medicine · 2025Observational
- Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation.Frontiers in physiology · 2025Article
- Short-term microgravity effects simulation does not affect fNIRS measures of cerebral oxygenation changes induced by cognitive load.Frontiers in physiology · 2025Article
- Differential Functional Changes in Visual Performance during Acute Exposure to Microgravity Analogue and Their Potential Links with Spaceflight-Associated Neuro-Ocular Syndrome.Diagnostics (Basel, Switzerland) · 2024Article
- Differential hemodynamic adaptations to tilt test in patients with idiopathic atrial fibrillation.Physiological reports · 2024Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Head-down tilt reduces the heart rate in postural tachycardia syndrome in acute setting: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The cardiovascular system is strongly dependent on the gravitational environment. Gravitational changes cause mechanical fluid shifts and, in turn, autonomic effectors influence systemic circulation and cardiac control. We implemented a tilt paradigm to (1) investigate the acute hemodynamic response across a range of directions of the gravitational vector, and (2) to generate specific dose-response relationships of this gravitational dependency. Methods and Results Twelve male subjects were tilted from 45° head-up tilt to 45° head-down tilt in 15° increments, in both supine and prone postures. We measured the steady-state hemodynamic response in a range of variables including heart rate, stroke volume, cardiac output, oxygen consumption, total peripheral resistance, blood pressure, and autonomic indices derived from heart rate variability analysis. There is a strong gravitational dependence in almost all variables considered, with the exception of oxygen consumption, whereas systolic blood pressure remained controlled to within ≈3% across the tilt range. Hemodynamic responses are primarily driven by differential loading on the baroreflex receptors, combined with differences in venous return to the heart. Thorax compression in the prone position leads to reduced venous return and increased sympathetic nervous activity, raising heart rate, and systemic vascular resistance while lowering cardiac output and stroke volume. Conclusions Gravitational dose-response curves generated from these data provide a comprehensive baseline from which to assess the efficacy of potential spaceflight countermeasures. Results also assist clinical management of terrestrial surgery in prone posture or head-down tilt positions.
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