ArticleCirculation. Cardiovascular interventions2022
Reduction of Gastrointestinal Bleeding in Patients With Heyde Syndrome Undergoing Transcatheter Aortic Valve Implantation.
Article in Circulation. Cardiovascular interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis.European heart journal · 2023Pooled it
- Diastolic delta best predicts paravalvular regurgitation after transcatheter aortic valve replacement as assessed by cardiac magnetic resonance: the APPOSE trial.European heart journal. Cardiovascular Imaging · 2023Trial
- Contrasting Outcomes in Heyde Syndrome: Diffuse Small-Bowel Angiodysplasia Versus Treatable Colonic Angiodysplasia.Cureus · 2026Article
- Prevention of Gastrointestinal Bleeding in Patients Receiving Direct Oral Anticoagulants: A Narrative Review and Practical Framework for Prescribers.Clinics and practice · 2026Review
- Aortic Bioprosthetic Stenosis Leading to Heyde Syndrome.JACC. Case reports · 2025Article
- Definition, Incidence, Prediction, and Prevention of Bleeding Events After Transcatheter Aortic Valve Implantation.Journal of clinical medicine · 2025Review
- Management challenges in Heyde syndrome: A case report of recurrent gastrointestinal bleeding and aortic stenosis in an octogenarian.Global cardiology science & practice · 2025Article
- Bleeding due to a Broken Heart Valve: Heyde's Syndrome Secondary to Severe Mitral Regurgitation.Gastro hep advances · 2025Article
- Recent advances in the treatment of refractory gastrointestinal angiodysplasia.United European gastroenterology journal · 2024Review
- Gastrointestinal Angiodysplasia Resolution After Transcatheter Aortic Valve Implantation.JAMA network open · 2024Article
- Reduced Rate of Anemia after Transcatheter Aortic Valve Replacement.Journal of clinical medicine · 2024Article
- Two Cases With Recurrent Challenges: Unraveling the Complexity of Heyde Syndrome With Rebleeding.Cureus · 2024Article
- Gastrointestinal bleeding associated to aortic valve stenosis (Heyde's syndrome): a case series and literature review.European heart journal. Case reports · 2023Article
- Did angiodysplasia associated with heyde's syndrome disappear spontaneously?: a case report.Journal of cardiothoracic surgery · 2023Article
- Transcatheter aortic valve implantation for patients with heyde syndrome: A literature review of case reports.Heliyon · 2023Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeyde syndrome is the co-occurrence of aortic stenosis and gastrointestinal bleeding secondary to angiodysplasias. Surgical aortic valve replacement effectively reduces bleeding, but the effects of transcatheter aortic valve implantation (TAVI) are largely unknown. This study aimed to describe the reduction of gastrointestinal bleeding in patients with Heyde syndrome after TAVI and to identify the factors associated with rebleeding.
methodsWe enrolled patients with Heyde syndrome from a prospective TAVI registry. Gastrointestinal bleeding episodes were assessed by the Bleeding Academic Research Consortium classification, and cumulative incidence functions were used to calculate cessation rates. Factors potentially associated with rebleeding were analyzed using logistic regression. Differences between Heyde and non-Heyde patients were assessed through a case-cohort study.
resultsBetween December 2008 and June 2020, 1111 patients underwent TAVI. There were 70 patients with Heyde syndrome (6.3%). In the first year following TAVI, gastrointestinal bleeding ceased in 46 of 70 patients (62% [95% CI, 50%-74%]). Bleeding episodes decreased from 3.2 (95% CI, 2.5-4.2) to 1.6 ([95% CI, 1.2-2.2]
conclusionsPatients with Heyde syndrome are at increased risk for periprocedural bleeding. Post-TAVI, gastrointestinal bleeding disappears in the majority of patients. Paravalvular leakage may curtail these clinical benefits.
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