ArticleBrain and behavior2022
Structural disconnectome mapping of cognitive function in poststroke patients.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The effect of transcranial magnetic stimulation on cognitive function in post-stroke patients: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Declined connectivity of thalamus and dorsomedial prefrontal cortex in post-stroke cognitive impairment delineated by lesion network mapping.Brain communications · 2026Article
- Frontoparietal Structural Network Disconnections Correlate With Outcome After a Severe Stroke.Human brain mapping · 2024Article
- Article
- The elusive metric of lesion load.Brain structure & function · 2023Review
- Functional and structural lesion network mapping in neurological and psychiatric disorders: a systematic review.Frontiers in neurology · 2023Article
- Structural disconnectome mapping of cognitive function in poststroke patients.Brain and behavior · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSequalae following stroke represents a significant challenge in current rehabilitation. The location and size of focal lesions are only moderately predictive of the diverse cognitive outcome after stroke. One explanation building on recent work on brain networks proposes that the cognitive consequences of focal lesions are caused by damages to anatomically distributed brain networks supporting cognition rather than specific lesion locations.
methodsTo investigate the association between poststroke structural disconnectivity and cognitive performance, we estimated individual level whole-brain disconnectivity probability maps based on lesion maps from 102 stroke patients using normative data from healthy controls. Cognitive performance was assessed in the whole sample using Montreal Cognitive Assessment, and a more comprehensive computerized test protocol was performed on a subset (n = 82).
resultsMultivariate analysis using Partial Least Squares on the disconnectome maps revealed that higher disconnectivity in right insular and frontal operculum, superior temporal gyrus and putamen was associated with poorer MoCA performance, indicating that lesions in regions connected with these brain regions are more likely to cause cognitive impairment. Furthermore, our results indicated that disconnectivity within these clusters was associated with poorer performance across multiple cognitive domains.
conclusionsThese findings demonstrate that the extent and distribution of structural disconnectivity following stroke are sensitive to cognitive deficits and may provide important clinical information predicting poststroke cognitive sequalae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.