Evidence map›Paper›PMID 35861564›Full record

ArticleInfection and immunity2022

CspZ FH-Binding Sites as Epitopes Promote Antibody-Mediated Lyme Borreliae Clearance.

Yi-Lin Chen, Ashley L Marcinkiewicz, Tristan A Nowak, Rakhi Tyagi Kundu, Zhuyun Liu, Ulrich Strych, Maria Elena Bottazzi, Wen-Hsiang Chen, Yi-Pin Lin

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  8. Development of an mRNA-lipid nanoparticle vaccine against Lyme disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yi-Lin ChenDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Ashley L MarcinkiewiczDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, New York, USA.
Tristan A NowakDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, New York, USA.
Rakhi Tyagi KunduDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Zhuyun LiuDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Ulrich StrychDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Maria Elena BottazziDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Wen-Hsiang ChenDepartment of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Yi-Pin LinDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, New York, USA.ORCID 0000-0002-5240-2031
Baylor College of Medicine · USNew York State Department of Health · USBaylor University · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI144891NCI NIH HHS P30 CA125123NIAID NIH HHS R21 AI144891
6 · The paper itself

Abstract

Transmitted by ticks, the bacterium Borrelia burgdorferi

Indexed as

BorreliaBorrelia burgdorferi GroupIxodesLyme DiseaseAnimalsAntibodiesBinding SitesComplement Factor HEpitopesMiceAntibodiesComplement Factor HEpitopesantibodiesBorreliaCspZfactor H-binding sitesLyme disease

Identifiers

PMID35861564
PMCPMC9302089
OpenAlexW4283806637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.