Evidence map›Paper›PMID 35861252›Full record

ArticleAmerican journal of hypertension2023

Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population.

Muhammad Imtiaz Ahmad, Phil M Mendys, Scott P Kelly, Lin Y Chen, Elsayed Z Soliman

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Muhammad Imtiaz AhmadDepartment of Internal Medicine, Section on Hospital Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin, USA.ORCID 0000-0002-6870-1722
Phil M MendysGlobal Medical Epidemiology, Worldwide Medical and Safety, Pfizer, New York, New York, USA.
Scott P KellyGlobal Medical Epidemiology, Worldwide Medical and Safety, Pfizer, New York, New York, USA.
Lin Y ChenDepartment of Internal Medicine, Cardiology Section, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Elsayed Z SolimanDepartment of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Pfizer (United States) · USMedical College of Wisconsin · USUniversity of Minnesota Medical Center · USWake Forest University · US

Funding

Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
$3.7M
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive DeclineR01HL141288 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2018 to 2021
$2.1M
Mentoring and Research to ClassifyAtrial CardiomyopathyK24HL155813 · NHLBI · UNIVERSITY OF MINNESOTA · PI Lin Yee Chen · 2021 to 2026
$770k
NHLBI NIH HHS K24 HL155813NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL141288
6 · The paper itself

Abstract

backgroundAtrial cardiopathy is associated with an increased risk of mortality. However, it is unclear whether this association is modified by hypertension, a risk factor for both atrial cardiopathy and mortality.

methodsThis analysis included 8,023 participants from the Third National Health and Nutrition Examination Survey. Electrocardiographic deep terminal negativity of P-wave in V1 ≥100 µV defined atrial cardiopathy. National Death Index was used to identify the date and cause of death. Cox proportional hazard analysis was used to examine the association of atrial cardiopathy with mortality among participants stratified by hypertension status.

resultsIn total 2.7% of the participants had atrial cardiopathy. Over a median follow-up of 14 years, 2,922 all-cause deaths occurred, of which 1,058 were CVD. All-cause death rates were almost double among participants with concomitant atrial cardiopathy and elevated blood pressure (BP) (120-129/<80), stage 1 (130-139/80-89), or stage 2 hypertension (≥140/≥90) compared to their counterparts in the same hypertension stages without atrial cardiopathy (47.8, 61.3, and 80.2 vs. 23, 24.7, and 44.8 per 1,000 person-years (PY), respectively). In multivariable-adjusted models, a stronger association between atrial cardiopathy and all-cause mortality was observed in the presence compared to the absence of hypertension (HR (95% CI): 1.59 (1.25-2.01) vs. 0.67 (0.41-1.10), respectively, interaction P-value = 0.009). Similarly, an association between atrial cardiopathy and cardiovascular disease (CVD) mortality was observed in the presence compared to the absence of hypertension (HR (95% CI): 1.64 (1.08-2.47) vs. 0.63 (0.20-2.00), respectively, interaction P-value = 0.20).

conclusionsConcomitant presence of high BP and atrial cardiopathy carries a higher risk of mortality, and the risk increases with higher BP levels.

Indexed as

Atrial FibrillationCardiovascular DiseasesHeart DiseasesHypertensionBlood PressureHumansNutrition SurveysRisk Factorsatrial cardiopathyblood pressuredeep terminal negativity of P-wave in V1hypertensionhypertension guidelinesmortality

Identifiers

PMID35861252
PMCPMC9793894
OpenAlexW4286016596

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.