ArticleStroke2022
Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study.
Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.Annals of medicine · 2026Pooled it
- Risk of cardiovascular disease and mortality among women with endometriosis: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- The abnormal coagulation status in endometriosis patients: a systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2026Pooled it
- Pooled it
- Endometriosis and aspirin: a systematic review.Frontiers in endocrinology · 2024Pooled it
- Attenuated cyclooxygenase-mediated vasodilation in cutaneous microvasculature with no difference in platelet aggregation in women with endometriosis.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Altered Blood Pressure Reflexes in Women With Endometriosis.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- Salsalate negatively impacts microvascular function in women with endometriosis.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Association between female infertility and stroke mortality: evidence from the PLCO cancer screening trial.Frontiers in endocrinology · 2024Trial
- Association between endometriosis and cardiovascular disease: a population-based cohort study.Journal of global health · 2026Article
- Association Between Endometriosis and Cardiovascular Disease: Insights From the UK Biobank.Journal of the American Heart Association · 2026Article
- SGLT2 Inhibitors and Mortality in Endometriosis With Type 2 Diabetes: A Propensity-Matched Analysis.JACC. Advances · 2026Article
- Endometriosis, subclinical cardiac remodeling, and cardiovascular risk: mechanistic insights from cardiac magnetic resonance and mediation analysis.Reproductive biology and endocrinology : RB&E · 2026Article
- Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines.F&S reports · 2026Article
- Longitudinal measurements of NO-mediated vasodilation and physical activity over 1 yr following endometriosis excision surgery: a passive experiment.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Endometriosis: A Review.JAMA · 2025Review
- Endometriosis and Cardiovascular Disease: Exploring Pathophysiological Interconnections and Risk Mechanisms.Diagnostics (Basel, Switzerland) · 2025Review
- Aspirin does not modify cardiovascular event risk in endometriosis in the California Teachers Study.European heart journal open · 2025Article
- Laparoscopically confirmed endometriosis and the risk of incident NAFLD: a prospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Unravelling the Causal Relationship between Endometriosis and the Risk for Developing Venous Thromboembolism: A Pooled Analysis.Thrombosis and haemostasis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrior research suggests that women with endometriosis are at greater risk of coronary heart disease. Therefore, our objective was to prospectively investigate the association between laparoscopically confirmed endometriosis and risk of incident stroke during 28 years of follow-up.
methodsParticipants in the NHSII cohort study (Nurses' Health Study II) were followed from 1989 when they were between the ages of 25 to 42 until 2017 for development of incident stroke (ischemic and hemorrhagic). Cox proportional hazard models were used to calculate hazard ratios and 95% CI, with adjustment for potential confounding variables (alcohol intake, body mass index at age 18, current body mass index, age at menarche, menstrual cycle pattern in adolescence, current menstrual cycle pattern, parity, oral contraceptive use history, smoking history, diet quality, physical activity, NSAID use, aspirin use, race/ethnicity, and income). We estimated the proportion of the total association mediated by history of hypertension, hypercholesterolemia, hysterectomy/oophorectomy, and hormone therapy. We also tested for effect modification by age (<50,
resultsWe documented 893 incident cases of stroke during 2 770 152 person-years of follow-up. Women with laparoscopically confirmed endometriosis had a 34% greater risk of stroke in multivariable-adjusted models (hazard ratio, 1.34 [95% CI, 1.10-1.62]), compared to those without a history of endometriosis. Of the total association of endometriosis with risk of stroke, the largest proportion was attributed to hysterectomy/oophorectomy (39% mediated [95% CI, 14%-71%]) and hormone therapy (16% mediated [95% CI, 5%-40%]). We observed no differences in the relationship between endometriosis and stroke by age, infertility history, body mass index, or menopausal status.
conclusionsWe observed that women with endometriosis were at elevated risk of stroke. Women and their health care providers should be aware of endometriosis history, maximize primary cardiovascular prevention, and discuss signs and symptoms of cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.