Evidence map›Paper›PMID 35861069›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2022

PLCβ2 Promotes VEGF-Induced Vascular Permeability.

Kathryn N Phoenix, Zhichao Yue, Lixia Yue, Chunxia G Cronin, Bruce T Liang, Luke H Hoeppner, Kevin P Claffey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Sex- and age-specific associations ofAnnals of medicine · 2026
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  11. Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kathryn N PhoenixCenter for Vascular Biology, Department of Cell Biology (K.N.P., K.P.C.), University of Connecticut Health Center, Farmington.
Zhichao YuePat and Jim Calhoun Cardiology Center (Z.Y., L.Y., C.G.C., B.T.L.), University of Connecticut Health Center, Farmington.
Lixia YuePat and Jim Calhoun Cardiology Center (Z.Y., L.Y., C.G.C., B.T.L.), University of Connecticut Health Center, Farmington.
Chunxia G CroninPat and Jim Calhoun Cardiology Center (Z.Y., L.Y., C.G.C., B.T.L.), University of Connecticut Health Center, Farmington.
Bruce T LiangPat and Jim Calhoun Cardiology Center (Z.Y., L.Y., C.G.C., B.T.L.), University of Connecticut Health Center, Farmington.
Luke H HoeppnerThe Hormel Institute, University of Minnesota, Austin (L.H.H.).ORCID 0000-0003-3948-4244
Kevin P ClaffeyCenter for Vascular Biology, Department of Cell Biology (K.N.P., K.P.C.), University of Connecticut Health Center, Farmington.ORCID 0000-0001-8211-0614
UConn Health · USUniversity of Minnesota · US

Funding

Vascular Pathophysiology and History Core (VPHC)P01HL070694 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HLA, TIMOTHY TUN · 2002 to 2013
$17.5M
MOLECULAR STUDIES OF VPF/VEGFR29CA064436 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CLAFFEY, KEVIN P. · 1995 to 1999
–
NCI NIH HHS R29 CA064436NHLBI NIH HHS P01 HL070694
6 · The paper itself

Abstract

backgroundRegulation of vascular permeability is critical to maintaining tissue metabolic homeostasis. VEGF (vascular endothelial growth factor) is a key stimulus of vascular permeability in acute and chronic diseases including ischemia reperfusion injury, sepsis, and cancer. Identification of novel regulators of vascular permeability would allow for the development of effective targeted therapeutics for patients with unmet medical need.

methodsIn vitro and in vivo models of VEGFA-induced vascular permeability, pathological permeability, quantitation of intracellular calcium release and cell entry, and phosphatidylinositol 4,5-bisphosphate levels were evaluated with and without modulation of PLC (phospholipase C) β2.

resultsGlobal knock-out of

conclusionsThe results implicate PLCβ2 as a key positive regulator of VEGF-induced vascular permeability through regulation of both calcium flux and phosphatidylinositol 4,5-bisphosphate levels at the cellular level. Targeting of PLCβ2 in a therapeutic setting may provide a novel approach to regulating vascular permeability in patients.

Indexed as

Capillary PermeabilityPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaRespiratory MucosaVascular Endothelial Growth Factor AAnimalsCalciumEndothelial CellsHumansLungMiceCalciumPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaPLCB2 protein, humanPlcb2 protein, mouseVascular Endothelial Growth Factor Ahomeostasisischemiapermeabilityreperfusionvascular endothelial growth factor A

Identifiers

PMID35861069
PMCPMC9492642
OpenAlexW4286492753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.