Evidence map›Paper›PMID 35861031›Full record

ArticleHeadache2022

Comparison and predictors of chronic migraine vs. new daily persistent headache presenting with a chronic migraine phenotype.

Karthik Nagaraj, Diana Y Wei, Francesca Puledda, Hsing-Yu Weng, Sadaf Waheed, Nicolas Vandenbussche, Jonathan J Y Ong, Peter J Goadsby

Open access · hybridAbstract read
In one paragraph

Article in Headache, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Osmophobia in Patients With Migraine: A Systematic Review and Meta-Analysis.World journal of otorhinolaryngology - head and neck surgery · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 6 countries.

Karthik NagarajHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Diana Y WeiHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-0644-7172
Francesca PuleddaHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hsing-Yu WengDepartment of Neurology, Taipei Municipal Wanfang Hospital, Taipei, Taiwan.
Sadaf WaheedHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nicolas VandenbusscheHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jonathan J Y OngHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-9197-9290
Peter J GoadsbyHeadache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBNational University of Singapore · SGTaipei Municipal YangMing Hospital · TWUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the clinical phenotype of patients with chronic migraine (CM) to patients with new daily persistent headache of the chronic migraine subtype (NDPH-CM).

methodsA study was conducted of CM (n = 257) and NDPH-CM (n = 76) from a tertiary headache center in the UK, and in the US of patients with daily CM (n = 60) and NDPH-CM (n = 22).

resultsFrom the UK cohort, the age of first headache onset was lower in CM (mean ± SD: 16 ± 12 years) than in NDPH-CM (mean ± SD: 23 ± 14 years; p < 0.001). There was a greater number of associated migrainous symptoms in CM compared to NDPH-CM (median and interquartile range: 6, 5-8 vs. 5, 4-7; p < 0.001). A family history of headache was more common in CM compared to NDPH-CM (82%, 202/248, vs. 53%, 31/59; p < 0.001). In the US cohort there were no differences. Osmophobia (B = -1.08; p = 0.002) and older age at presentation to the clinic (B = -0.06; p = 0.001) were negative predictors of NDPH-CM.

conclusionNDPH-CM is relatively less migrainous than CM in the UK cohort. Family history of headache is less common in NDPH-CM, with negative predictors for NDPH-CM including osmophobia and older age of presentation to the clinic. More work is required to understand the chronic migraine phenotype of new daily persistent headache.

Indexed as

Headache DisordersMigraine DisordersHeadacheHumansPhenotypechronic migrainemedication overuse headachenew daily persistent headache

Identifiers

PMID35861031
PMCPMC9545870
OpenAlexW4286007544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.