Evidence map›Paper›PMID 35860850›Full record

ReviewCell proliferation2022

Brain-immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders.

Fangyi Zhao, Bingjin Li, Wei Yang, Tongtong Ge, Ranji Cui

Abstract readReview
In one paragraph

Review in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  12. Frontiers in cellular and infection microbiology · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Editorial: Neuroinflammation and cognitive impairment.Frontiers in aging neuroscience · 2024
    Article
  19. Article
  20. Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fangyi ZhaoJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Bingjin LiJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0000-0002-7509-3163
Wei YangJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0000-0002-3944-4536
Tongtong GeJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Ranji CuiJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0000-0002-1129-3772

Funding

Graduate Innovation Fund of Jilin University 101832018C076Jilin Science and Technology Agency 20180414050GHJilin Science and Technology Agency 20180519003JHJilin Science and Technology Agency 20190701078GHNational Key R&D Program of China #2018YFC1311600National Natural Science Foundation of China 31571126National Natural Science Foundation of China 31971078National Natural Science Foundation of China 81871070National Natural Science Foundation of China 81971276
6 · The paper itself

Abstract

objectivesCognitive dysfunction has been identified as a major symptom of a series of psychiatric disorders. Multidisciplinary studies have shown that cognitive dysfunction is monitored by a two-way interaction between the neural and immune systems. However, the specific mechanisms of cognitive dysfunction in immune response and brain immune remain unclear. MATERIALS AND

methodsIn this review, we summarized the relevant research to uncover our comprehension of the brain-immune interaction mechanisms underlying cognitive decline.

resultsThe pathophysiological mechanisms of brain-immune interactions in psychiatric-based cognitive dysfunction involve several specific immune molecules and their associated signaling pathways, impairments in neural and synaptic plasticity, and the potential neuro-immunological mechanism of stress.

conclusionsTherefore, this review may provide a better theoretical basis for integrative therapeutic considerations for psychiatric disorders associated with cognitive dysfunction.

Indexed as

Cognitive DysfunctionMental DisordersBrainHumansNeuronal Plasticity

Identifiers

PMID35860850
PMCPMC9528770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.