Evidence map›Paper›PMID 35860792›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Mayo normative studies: A conditional normative model for longitudinal change on the Auditory Verbal Learning Test and preliminary validation in preclinical Alzheimer's disease.

Eva C Alden, Emily S Lundt, Erin L Twohy, Teresa J Christianson, Walter K Kremers, Mary M Machulda, Clifford R Jack, David S Knopman, Michelle M Mielke, Ronald C Petersen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  5. Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eva C AldenDivision of Neurocognitive Disorders Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA.
Emily S LundtDivision of Clinical Trials and Biostatistics Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA.
Erin L TwohyDivision of Clinical Trials and Biostatistics Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA.
Teresa J ChristiansonDivision of Clinical Trials and Biostatistics Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA.
Walter K KremersDivision of Clinical Trials and Biostatistics Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA.
Mary M MachuldaDivision of Neurocognitive Disorders Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA.
Clifford R JackDepartment of Radiology Mayo Clinic Rochester Minnesota USA.
David S KnopmanDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Michelle M MielkeDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Ronald C PetersenDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Nikki H StrickerDivision of Neurocognitive Disorders Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Reproductive risk factors for Alzheimer's disease dementia and pathologyRF1AG055151 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M, ROCCA, WALTER A · 2017 to 2017
$4.0M
NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R37 AG011378NIA NIH HHS RF1 AG055151NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

Introduction: The aim of this study was to develop a conditional normative model for Rey's Auditory Verbal Learning Test (AVLT) that accounts for practice effects. Methods: In our normative sample, robust conditional norms were derived from 1001 cognitively unimpaired (CU) adults ages 50 to 89 who completed the AVLT up to eight times. Linear mixed-effects models adjusted for baseline performance, prior test exposures, time, demographics, and interaction terms. In our preliminary validation, mean performance on conditional and typical normative scores across two to four completed follow-up tests in preclinical Alzheimer's disease participants at baseline with positive amyloid and tau positron emission ( Results: AVLT performance using typical norms did not differ across A+T+ and A-T- groups. Conditional norms z-scores were lower in the A+T+ relative to the A-T- group for 30-minute recall ( Discussion: Conditional normative methods that account for practice effects show promise for identifying longitudinal cognitive decline.

Indexed as

Alzheimer's diseaseamyloidbiomarkermemorymild cognitive impairmentneuropsychologypractice effectsreliable change index (RCI)Rey Auditory Verbal Learning Testrobust normative datastandardized regression‐based change scores (SRB)tautransitional cognitive declinevalidity

Identifiers

PMID35860792
PMCPMC9286327
OpenAlexW4285506105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.