Evidence map›Paper›PMID 35860667›Full record

ArticleFrontiers in aging neuroscience2022

Genetic Analysis of Six Transmembrane Protein Family Genes in Parkinson's Disease in a Large Chinese Cohort.

Yuwen Zhao, Kailin Zhang, Hongxu Pan, Yige Wang, Xiaoxia Zhou, Yaqin Xiang, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. What We Know About TMEM175 in Parkinson's Disease.CNS neuroscience & therapeutics · 2025
    Review
  6. Review
  7. Comprehensive pan-cancer analysis reveals prognostic implications of TMEM92 in the tumor immune microenvironment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  8. Article
  9. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Kailin ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hongxu PanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yige WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiaoxia ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yaqin XiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
Jieqiong TanCentre for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
Xinxiang YanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Jinchen LiNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Zhenhua LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Parkinson's disease (PD) is a neurodegenerative disorder with the manifestation of motor symptoms and non-motor symptoms. Previous studies have indicated the role of several transmembrane (TMEM) protein family genes in PD pathogenesis. Materials and Methods: In order to better investigate the genetic role of PD-related TMEM protein family genes in PD, including Results: One hundred rare damaging or loss of function variants of six genes were found at the threshold of MAF < 0.1%. Three rare Dmis variants of Conclusion: We performed a large case-control study to systematically investigate the role of several PD-related TMEM protein family genes in PD. We identified three PD-specific variants in

Indexed as

burden analysiscommon variantsgenetic analysisParkinson’s diseaserare variantsTMEM protein family genes

Identifiers

PMID35860667
PMCPMC9289399
OpenAlexW4283797757

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.