Evidence map›Paper›PMID 35860666›Full record

ReviewFrontiers in aging neuroscience2022

Protective Effects of Polysaccharides in Neurodegenerative Diseases.

Yinying Wang, Rongsha Chen, Zhongshan Yang, Qian Wen, Xia Cao, Ninghui Zhao, Jinyuan Yan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Jujube Polysaccharide Promotes Neuroprotection and Longevity inInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yinying WangThe Central Laboratory of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Rongsha ChenThe Central Laboratory of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Zhongshan YangYunnan Provincial Key Laboratory of Molecular Biology for Sino Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Qian WenThe Neurosurgery Department of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Xia CaoThe Central Laboratory of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Ninghui ZhaoThe Neurosurgery Department of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Jinyuan YanThe Central Laboratory of the Second Affiliated Hospital, Kunming Medical University, Kunming, China.
Kunming Medical University · CNYunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases (NDs) are characterized by progressive degeneration and necrosis of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease and others. There are no existing therapies that correct the progression of these diseases, and current therapies provide merely symptomatic relief. The use of polysaccharides has received significant attention due to extensive biological activities and application prospects. Previous studies suggest that the polysaccharides as a candidate participate in neuronal protection and protect against NDs. In this review, we demonstrate that various polysaccharides mediate NDs, and share several common mechanisms characterized by autophagy, apoptosis, neuroinflammation, oxidative stress, mitochondrial dysfunction in PD and AD. Furthermore, this review reveals potential role of polysaccharides

Indexed as

Alzheimer’s diseaseHuntington’s diseasemechanismParkinson’s diseasepolysaccharides

Identifiers

PMID35860666
PMCPMC9289469
OpenAlexW4283799990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.