ArticleFrontiers in physiology2022
Red Blood Cell Morphologic Abnormalities in Patients Hospitalized for COVID-19.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Subacute-Onset Anemia Following COVID-19 Vaccine Combination with ChAdOx (AstraZeneca) and BNT162b2 (BioNTech, Pfizer)-A Case Report.Reports (MDPI) · 2026Article
- Personalized Exercise Training Modulates Red Blood Cell Rheology and Morphology in Long COVID.International journal of molecular sciences · 2026Article
- Hematologic and Computed Tomography Features for Discriminating COVID-19 From Non-COVID-19 Pneumonia.Archives of Razi Institute · 2025Article
- Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion.Nature communications · 2025Article
- Article
- Review
- Haematological Manifestations of SARS-CoV-2: Insights into Erythropoiesis, Hepcidin Regulation, and Cytokine Storm.International journal of molecular sciences · 2025Review
- Laboratory Biochemical and Hematological Parameters: Early Predictive Biomarkers for Diagnosing Hepatitis C Virus Infection.Journal of clinical laboratory analysis · 2024Article
- Red Blood Cell Morphology Is Associated with Altered Hemorheological Properties and Fatigue in Patients with Long COVID.Biology · 2024Article
- Morphology and Function of Red Blood Cells in COVID-19 Patients: Current Overview 2023.Life (Basel, Switzerland) · 2024Article
- Article
- SARS-CoV-2 Infection and Anemia-A Focus on RBC Deformability and Membrane Proteomics-Integrated Observational Prospective Study.Microorganisms · 2024Article
- Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease.Heliyon · 2024Article
- An early warning indicator of mortality risk in patients with COVID-19: the neutrophil extracellular traps/neutrophilic segmented granulocyte ratio.Frontiers in immunology · 2024Article
- SARS-CoV-2 Impact on Red Blood Cell Morphology.Biomedicines · 2023Article
- Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study.Hematology reports · 2023Article
- Review
- Recent advances in micro-sized oxygen carriers inspired by red blood cells.Science and technology of advanced materials · 2023Review
- SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients.International journal of molecular sciences · 2022Article
- Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC).Metabolites · 2022Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral blood smear is a simple laboratory tool, which remains of invaluable help for diagnosing primary and secondary abnormalities of blood cells despite advances in automated and molecular techniques. Red blood cells (RBCs) abnormalities are known to occur in many viral infections, typically in the form of mild normo-microcytic anemia. While several hematological alterations at automated complete blood count (including neutrophilia, lymphopenia, and increased red cell distribution width-RDW) have been consistently associated with severity of COVID-19, there is scarce information on RBCs morphological abnormalities, mainly as case-reports or small series of patients, which are hardly comparable due to heterogeneity in sampling times and definition of illness severity. We report here a systematic evaluation of RBCs morphology at peripheral blood smear in COVID-19 patients within the first 72 h from hospital admission. One hundred and fifteen patients were included, with detailed collection of other clinical variables and follow-up. A certain degree of abnormalities in RBCs morphology was observed in 75 (65%) patients. Heterogenous alterations were noted, with spiculated cells being the more frequent morphology. The group with >10% RBCs abnormalities had more consistent lymphopenia and thrombocytopenia compared to those without abnormalities or <10% RBCs abnormalities (
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